The Effects of a Chalcone Derivative on Memory, Hippocampal Corticosterone and Bdnf Levels in Adult Rats Publisher Pubmed



Asadzadeh Bayqara S¹ ; Aghazadeh Yamchelu M¹ ; Abdolahzadeyadegari S¹ ; Farhadi M¹ ; Nadjafi S² ; Fahanik Babaei J³ ; Hosseini N² Show Affiliations
Source: International Journal of Neuroscience Published:2024

Abstract

Purpose/Aim of the study: Since chalcones belong to the flavonoid family, the effects of a new synthetic chalcone derivative on memory, chronic stress, and expression of hippocampal BDNF gene were studied.Materials and methods: In this experiment, the male wistar rats were placed under restraint stress (6 h/day) for 21 days and then treated with a newly synthesized chalcone, containing methoxy on the aromatic rings or vehicles (20 mg/kg, intraperitoneal, IP). After the behavioral Passive avoidance, Open field, and Morris water maze tests, the levels of serum corticosterone (CORT) and hippocampal brain-derived neurotrophic factor (BDNF) were analyzed.Results: Results of these tests presented significant differences between the Stress (St) and Chalcone (Ch) groups. Chronic stress led to high CORT levels and impaired memory functions. Moreover, a single dose of synthetic chalcone in the St group could postpone memory impairments. Furthermore, a 20 mg/kg IP injection of chalcone markedly attenuated the decrease of hippocampal BDNF.Conclusions: It has been already proposed that flavonoids have beneficial effects on different types of memory. According to these results, further investigations are required to explore other factors besides BDNF that could be acutely modulated by chalcones. © 2022 Informa UK Limited, trading as Taylor & Francis Group.