Biophysical and Ultrasonographic Changes in Early Patch/Plaque Stage of Mycosis Fungoides, Compared With Uninvolved Skin Publisher Pubmed



Yazdanparast T¹ ; Yazdani K² ; Ahmad Nasrollahi S¹ ; Izadi Firouzabadi L¹ ; Humbert P³ ; Khatami A¹ ; Kassir M⁴ ; Firooz A^{1, 5} Show Affiliations
Source: Skin Research and Technology Published:2021

Abstract

Background: The goal of this study was evaluation of the skin biophysical properties in early patch/plaque stage of mycosis fungoides (MF) and its comparison with uninvolved skin in order to gain a better understanding of the pathogenesis of diseases. Materials and Methods: The stratum corneum hydration, transepidermal water loss (TEWL), surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, R5), thickness, and echo density of epidermis and dermis were measured on lesions of 21 patients and compared with controls (average measures of uninvolved perilesional and symmetrical skins) by paired sample t test. Results: Stratum corneum hydration (P < 0.001) and echo density of dermis (P = 0.044) were significantly lower, whereas pH (P-value = 0.007), erythema (P < 0.001), and melanin content (P = 0.007) were significantly higher in lesions. There was not any significant difference in TEWL, friction index, sebum, temperature, R0, R2, R5, thickness of epidermis and dermis, and echo density of epidermis between lesions and normal skin. Conclusion: Parapsoriasis/MF lesions are specified by a set of certain changes in biophysical properties which are mainly correlated with histological changes. These sets of alterations may help in noninvasive, early diagnosis of parapsoriasis/MF. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd