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Synthesis, Reaction and Biological Activity of Pyrazolo[5,1-C][1,2,4]Benzotriazine 5-Oxides Publisher



Ziarani GM1 ; Mostofi M1 ; Lashgari N1 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Alzahra University, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology, Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Politics and Religion Journal Published:2018


Abstract

[1,2,4]Benzotriazine fused to pyrazole ring is a privileged heterocyclic scaffold present in numerous pharmacologically active compounds. Till date, various pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their deoxy analogues, possessing a broad spectrum of potent pharmacological activities, have been reported. In this review, we highlighted synthesis, chemical reactions, medicinal chemistry aspects and applications of fused pyrazole derivatives of [1,2,4]benzotriazine analogues reported so far. © 2018 The Japan Institute of Heterocyclic Chemistry Received.