Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis

Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis Publisher Pubmed

Motamed F¹ ; Mehrabani S¹ ; Monajemzadeh M¹ ; Ashtiani MTH¹ ; Hosseinverdi S² ; Houshmand M³ ; Aryani O³ ; Najafi M¹ ; Farahmand F¹ ; Kiani MA¹ ; Khodadad A¹ ; Fallahi GH¹ ; Khatami G¹ ; Rezaei N^{2, 4, 5}

Show Affiliations

1. Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics, Special Medical Center, Tehran, Iran
4. Department of Immunology, Molecular Immunology Research Center and Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Turkish Journal of Gastroenterology Published:2015

Abstract

Background/Aims: There are few data concerning the incidence of alpha 1 antitrypsin (AAT) deficiency, a most common genetic cause of liver disease, among children with neonatal cholestasis in Iran. Thus, this study was performed to analyze AAT deficiency in this group of patients. Materials and Methods: DNA samples from neonatal cholestasis were investigated for Pi S and Pi Z alleles, using polymerase chain reaction-restriction fragment length polymorphism. Results: Thirty patients with neonatal cholestasis were enrolled. Among those who underwent biopsies, the results revealed neonatal hepatitis in 19, bile duct paucity in 1, steatohepatitis in 1, bile duct proliferation in 1, cirrhosis in 2, fibrosis in 2, and extrahepatic biliary atresia in 1 patient. No mutant allele was found in any case. Conclusion: The incidence of AAT deficiency is very low in our region; therefore, screening for AAT is not recommended as a cause of neonatal cholestasis in Iran. © Copyright 2015 by The Turkish Society of Gastroenterology.

Style	Citing Format
MLA	Motamed F, et al.. "Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis." Turkish Journal of Gastroenterology, vol. 26, no. 3, 2015, pp. 251-253.
APA	Motamed F, Mehrabani S, Monajemzadeh M, Ashtiani MTH, Hosseinverdi S, Houshmand M, Aryani O, Najafi M, Farahmand F, Kiani MA, Khodadad A, Fallahi GH, Khatami G, Rezaei N (2015). Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis. Turkish Journal of Gastroenterology, 26(3), 251-253.
Chicago	Motamed F, Mehrabani S, Monajemzadeh M, Ashtiani MTH, Hosseinverdi S, Houshmand M, Aryani O, et al.. "Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis." Turkish Journal of Gastroenterology 26, no. 3 (2015): 251-253.
Harvard	Motamed F et al. (2015) 'Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis', Turkish Journal of Gastroenterology, 26(3), pp. 251-253.
Vancouver	Motamed F, Mehrabani S, Monajemzadeh M, Ashtiani MTH, Hosseinverdi S, Houshmand M, et al.. Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis. Turkish Journal of Gastroenterology. 2015;26(3):251-253.
BibTex	@article{ author = {Motamed F and Mehrabani S and Monajemzadeh M and Ashtiani MTH and Hosseinverdi S and Houshmand M and Aryani O and Najafi M and Farahmand F and Kiani MA and Khodadad A and Fallahi GH and Khatami G and Rezaei N}, title = {Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis}, journal = {Turkish Journal of Gastroenterology}, volume = {26}, number = {3}, pages = {251-253}, year = {2015} }
RIS	TY - JOUR AU - Motamed F AU - Mehrabani S AU - Monajemzadeh M AU - Ashtiani MTH AU - Hosseinverdi S AU - Houshmand M AU - Aryani O AU - Najafi M AU - Farahmand F AU - Kiani MA AU - Khodadad A AU - Fallahi GH AU - Khatami G AU - Rezaei N TI - Low Incidence of Alpha 1 Antitrypsin Deficiency in Iranian Patients With Neonatal Cholestasis JO - Turkish Journal of Gastroenterology VL - 26 IS - 3 SP - 251 EP - 253 PY - 2015 ER -

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