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Epidemiological, Endoscopic, Clinical, and Pathological Features of Patients With Celiac Diseases in Southern Littoral of Caspian Sea Publisher



Bari Z1 ; Hadipour M2 ; Fakheri H1 ; Kazemi A1 ; Maleki I1 ; Taghvaei T1 ; Hosseini V1 ; Valizadeh SM1 ; Masoumi D3 ; Shahbazkhani B4 ; Shirvani JS5 ; Fakheri ST6 ; Ebrahimi R6
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Gut and Liver Research Center, Non-communicable Disease Research Institute, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Student of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Gastroenterology, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
  6. 6. Gut and Liver Research Center, Non-communicable Disease Research Institute, Mazandaran University of Medical Sciences, Sari, Iran

Source: Middle East Journal of Digestive Diseases Published:2023


Abstract

Background: Celiac disease is an autoimmune disorder resulting from gluten consumption in genetically predisposed individuals. The present study investigated the epidemiological, endoscopic, and clinicopathological features of patients with celiac disease in the southern littoral of the Caspian Sea. Methods: 140 patients with celiac disease were interviewed and examined regarding demographic characteristics, clinical symptoms, and serologic, endoscopic, and pathological findings. Results: 44 (31.4%) of the patients were male and 68.6% were female. The mean age of the patients at diagnosis was 27.13 ± 13.4 years (ranging from 2 to 60 years). The most common gastrointestinal (GI) symptoms were bloating (47.8%), abdominal pain (47.1%) and diarrhea (30.7%), respectively. Also, 17 (12.1%) patients did not complain of any GI symptoms.18 (12.8%) patients had aphthous stomatitis, 10.7% had dermatitis herpetiformis, 3.6% suffered from itching without a rash, two (1.4%) mentioned psoriasis and one (0.7%) had lichen planus. 19 (19.7%) of the female patients complained of menstrual bleeding disorders, 4% mentioned infertility, and 2% experienced primary amenorrhea. The most common comorbid condition was hypothyroidism in 16 (11.4%) patients. The most common endoscopic finding was duodenal scalloping (37.25%). In addition, 7.8% of the patients had a normal endoscopic appearance. 43 (30.7%) patients were classified as Marsh IIIC, 25.7% Marsh IIIB, 17.8% Marsh IIIA, 12.8% Marsh II and 12.8% were classified as Marsh I. Conclusion: Since celiac disease can present with non-GI manifestations and the majority of our patients had Marsh III classification, it seems that celiac disease must be considered as a routine screening test in GI clinics, and also, it should be kept in mind as a differential diagnosis in other specialty fields. © 2023 Shiraz University of Medical Sciences. All rights reserved.
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