Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives

Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives Publisher Pubmed

Yazzaf R ; Asadi M ; Mahdavic M

Source: Current Organic Synthesis Published:2025

Abstract

Introduction: 1,4-oxazepine is a significant structural motif found in several bioactive molecules used in the treatment of diseases such as psychotic disorders. Methods: Therefore, developing novel methodologies for its preparation is of great interest to medicinal chemists. Results: These seven-membered heterocycles are generated through the intramolecular cyclization of Betti bases, which are propargylated using propargyl bromide as the source of the triple bond in the presence of a base. Conclusion: This efficient and straightforward protocol proceeds under mild, metal-free conditions and has been shown to be applicable to a broad range of aldehydes and 2-aminopyridines. © 2025 Elsevier B.V., All rights reserved.

Style	Citing Format
MLA	Yazzaf R, Asadi M, Mahdavic M. "Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives." Current Organic Synthesis, vol. 22, no. 6, 2025, pp. 747-753.
APA	Yazzaf R, Asadi M, Mahdavic M (2025). Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives. Current Organic Synthesis, 22(6), 747-753.
Chicago	Yazzaf R, Asadi M, Mahdavic M. "Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives." Current Organic Synthesis 22, no. 6 (2025): 747-753.
Harvard	Yazzaf R, Asadi M, Mahdavic M (2025) 'Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives', Current Organic Synthesis, 22(6), pp. 747-753.
Vancouver	Yazzaf R, Asadi M, Mahdavic M. Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives. Current Organic Synthesis. 2025;22(6):747-753.
BibTex	@article{ author = {Yazzaf R and Asadi M and Mahdavic M}, title = {Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives}, journal = {Current Organic Synthesis}, volume = {22}, number = {6}, pages = {747-753}, year = {2025} }
RIS	TY - JOUR AU - Yazzaf R AU - Asadi M AU - Mahdavic M TI - Base Mediated 7-Exo-Dig Intramolecular Cyclization of Betti-Propargyl Precursors: An Efficient Approach to 1,4-Oxazepine Derivatives JO - Current Organic Synthesis VL - 22 IS - 6 SP - 747 EP - 753 PY - 2025 ER -

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