Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Probiotics on Gastrointestinal Symptoms and Microbiota in Patients With Celiac Disease: A Systematic Review and Meta-Analysis on Clinical Trials Publisher Pubmed



Mozafarybazargany M1 ; Khonsari M2 ; Sokoty L3 ; Ejtahed HS4, 5 ; Qorbani M3, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Clinical Research Development Unit, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical and Experimental Medicine Published:2023


Abstract

Gluten-free diet (GFD) is the most effective method to manage celiac disease (CD). Many patients do not reach the complete symptom alleviation, even by strict GFD. Recent studies have reported inconsistent results regarding the beneficial benefits of taking probiotics. Therefore, we aimed to evaluate the effects of probiotics on gastrointestinal (GI) symptoms and the possible underlying causes in CD and celiac disease autoimmunity (CDA) patients. Databases, including PubMed, Scopus, Embase, Web of Science and Google Scholar, were searched for clinical trials published until July 2022 about assessing the effects of probiotics or synbiotics on CD or CDA patients. We collected data on GI symptoms, CD markers, inflammatory and immune responses, adverse events, and gut microbiota. A random effect meta-analysis was used to estimate the pooled standardized mean difference (SMD) and confidence interval (CI). We screened 7234 articles, of which 14 were included in the qualitative analysis and 5 in the quantitative analysis. Probiotics might alleviate GI symptoms, especially in the highly symptomatic patients, and improve immune response in CD and CDA patients. Results of the meta-analysis showed that probiotics increased the abundance of Bifidobacterium (SMD: 0.72, 95%CI (0.13, 1.30) and Lactobacillus (SMD: 0.49, 95%CI (0.18, 0.80) as compared with placebo. Probiotics did not increase the adverse events compared to the placebo. Probiotics might alleviate GI symptoms and immune response and improve dysbiosis in CD and CDA patients. However, high-quality clinical trials are needed to increase the level of evidence. Also, the most suitable combination of probiotics is yet to find. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Related Docs
1. Gut Microbiota, Angiotensin-Converting Enzyme, Celiac Disease, and Risk of Covid-19 Infection: A Review, Gastroenterology and Hepatology from Bed to Bench (2021)
2. Efficacy of Dietary Supplements on Mortality and Clinical Outcomes in Adults With Sepsis and Septic Shock: A Systematic Review and Network Meta-Analysis, Clinical Nutrition (2024)
3. The Possible Role of Pathogenic and Non-Pathogenic Bacteria in Initiation and Exacerbation of Celiac Disease; a Comprehensive Review, Current Pharmaceutical Biotechnology (2020)
4. Are Alterations Needed in Silybum Marianum (Silymarin) Administration Practices? a Novel Outlook and Meta-Analysis on Randomized Trials Targeting Liver Injury, BMC Complementary Medicine and Therapies (2025)
5. Cardiovascular Outcomes of Sglt-2 Inhibitors’ Subtypes in Type 2 Diabetes; an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Diabetes and Metabolic Disorders (2025)
6. Effects of Silymarin Supplementation on Liver and Kidney Functions: A Systematic Review and Dose–Response Meta-Analysis, Phytotherapy Research (2024)
Experts (# of related papers)
View all Related Experts
Masoud Mohammad Pour (1)
Kaveh Hosseini (1)