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Decoding the Role of Neil1 Gene in Dna Repair and Lifespan: A Literature Review With Bioinformatics Analysis Publisher Pubmed



Mohajeri Khorasani A1, 2, 3 ; Raghibi A4 ; Haj Mohammad Hassani B1, 2, 3 ; Bolbolizadeh P5 ; Amali A6 ; Sadeghi M1, 2, 3 ; Farshidi N7, 8 ; Dehghani A9 ; Mousavi P2
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  2. 2. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  3. 3. Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416634793, Iran
  5. 5. Student Research Committee, Faculty of Para-Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  6. 6. School of Infection & Immunity, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
  7. 7. Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  8. 8. USERN Office, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran
  9. 9. Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, 7916613885, Iran

Source: Advanced Biology Published:2024


Abstract

Longevity, the length of an organism's lifespan, is impacted by environmental factors, metabolic processes, and genetic determinants. The base excision repair (BER) pathway is crucial for maintaining genomic integrity by repairing oxidatively modified base lesions. Nei-like DNA Glycosylase 1 (NEIL1), part of the BER pathway, is vital in repairing oxidative bases in G-rich DNA regions, such as telomeres and promoters. Hence, in this comprehensive review, it have undertaken a meticulous investigation of the intricate association between NEIL1 and longevity. The analysis delves into the multifaceted aspects of the NEIL1 gene, its various RNA transcripts, and the diverse protein isoforms. In addition, a combination of bioinformatic analysis is conducted to identify NEIL1 mutations, transcription factors, and epigenetic modifications, as well as its lncRNA/pseudogene/circRNA-miRNA-mRNA regulatory network. The findings suggest that the normal function of NEIL1 is a significant factor in human health and longevity, with defects in NEIL1 potentially leading to various cancers and related syndromes, Alzheimer's disease, obesity, and diabetes. © 2024 Wiley-VCH GmbH.
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