Tehran University of Medical Sciences

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Histological Evaluation of Products of Conception, Who Benefits From It? Publisher Pubmed



Soltanghoraee H1 ; Mohazzab A2, 3 ; Soltani A4 ; Ansaripour S1 ; Tavakoli M1 ; Rafati M1 ; Zarnani AH5 ; Ghaffari SR1
Authors

Source: Fetal and Pediatric Pathology Published:2023


Abstract

Background: Histopathological evaluation of the first trimester pregnancy loss has always been controversial. Although it is recommended, it is not a part of guidelines. Methods: Six hundred eighty-six samples in a referral infertility clinic were evaluated microscopically and categorized. Two hundred ninety-five cases were evaluated by genetic methods (Multiplex Ligation-dependent Probe Amplification). Results: From 569 samples with chorionic villi, 361 cases had history of three or more abortions. 18.3% of this group showed chronic intervillous of unknown etiology (CIUE) and 8.3% revealed intervilli fibrin deposition, both pathologies with a high risk of recurrence. History of a live child was significantly higher in CIUE group. 29% of genetically evaluated cases had a chromosomal abnormality. Conclusion: Histological evaluation of recurrent pregnancy loss could illuminate the cause of abortion in relatively acceptable percentage of cases, especially in mothers with higher number of previous abortion, mothers with a history of live child and in referral centers. © 2022 Taylor & Francis Group, LLC.