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Histological Evaluation of Products of Conception, Who Benefits From It? Publisher Pubmed



Soltanghoraee H1 ; Mohazzab A2, 3 ; Soltani A4 ; Ansaripour S1 ; Tavakoli M1 ; Rafati M1 ; Zarnani AH5 ; Ghaffari SR1
Authors
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Authors Affiliations
  1. 1. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  2. 2. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  4. 4. Avicenna Fertility Clinic, Avicenna Research Institute, ACECR, Tehran, Iran
  5. 5. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Fetal and Pediatric Pathology Published:2023


Abstract

Background: Histopathological evaluation of the first trimester pregnancy loss has always been controversial. Although it is recommended, it is not a part of guidelines. Methods: Six hundred eighty-six samples in a referral infertility clinic were evaluated microscopically and categorized. Two hundred ninety-five cases were evaluated by genetic methods (Multiplex Ligation-dependent Probe Amplification). Results: From 569 samples with chorionic villi, 361 cases had history of three or more abortions. 18.3% of this group showed chronic intervillous of unknown etiology (CIUE) and 8.3% revealed intervilli fibrin deposition, both pathologies with a high risk of recurrence. History of a live child was significantly higher in CIUE group. 29% of genetically evaluated cases had a chromosomal abnormality. Conclusion: Histological evaluation of recurrent pregnancy loss could illuminate the cause of abortion in relatively acceptable percentage of cases, especially in mothers with higher number of previous abortion, mothers with a history of live child and in referral centers. © 2022 Taylor & Francis Group, LLC.