Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach

Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach Publisher

Iman M¹ ; Peroomian T² ; Davood A² ; Amini M³ ; Sardari S⁴ ; Azerang P⁴

Show Affiliations

1. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Bioinformatics and Drug Design, Institute Pasteur, Tehran, Iran

Source: Pharmaceutical Chemistry Journal Published:2016

Abstract

Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitroimidazole moiety proved to be the most potent compound. It was more active than the reference drugs fluconazole and ketoconazole against S. cerevisiae. © 2016, Springer Science+Business Media New York.

Style	Citing Format
MLA	Iman M, et al.. "Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach." Pharmaceutical Chemistry Journal, vol. 49, no. 10, 2016, pp. 687-693.
APA	Iman M, Peroomian T, Davood A, Amini M, Sardari S, Azerang P (2016). Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach. Pharmaceutical Chemistry Journal, 49(10), 687-693.
Chicago	Iman M, Peroomian T, Davood A, Amini M, Sardari S, Azerang P. "Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach." Pharmaceutical Chemistry Journal 49, no. 10 (2016): 687-693.
Harvard	Iman M et al. (2016) 'Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach', Pharmaceutical Chemistry Journal, 49(10), pp. 687-693.
Vancouver	Iman M, Peroomian T, Davood A, Amini M, Sardari S, Azerang P. Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach. Pharmaceutical Chemistry Journal. 2016;49(10):687-693.
BibTex	@article{ author = {Iman M and Peroomian T and Davood A and Amini M and Sardari S and Azerang P}, title = {Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach}, journal = {Pharmaceutical Chemistry Journal}, volume = {49}, number = {10}, pages = {687-693}, year = {2016} }
RIS	TY - JOUR AU - Iman M AU - Peroomian T AU - Davood A AU - Amini M AU - Sardari S AU - Azerang P TI - Design, Synthesis and Evaluation of New Azoles As Antifungal Agents: A Molecular Hybridization Approach JO - Pharmaceutical Chemistry Journal VL - 49 IS - 10 SP - 687 EP - 693 PY - 2016 ER -

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