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Concurrent Glial Tumors in the Setting of a Nonsyndromic Adjacent/Colliding Meningioma: Illustrative Cases Publisher



Pourrashidi A1 ; Nahang FH2 ; Gookizadeh P2 ; Yarandi KK2 ; Amirjamshidi A2 ; Nilipour Y3 ; Shirani M2
Authors
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Authors Affiliations
  1. 1. Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
  2. 2. Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Toos Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Neurosurgery: Case Lessons Published:2025


Abstract

BACKGROUND Meningioma, a common and mostly benign intracranial and spinal tumor, can coexist with other malignant tumors. Such a scenario is very rare in patients with no history of radiation therapy or phakomatosis. In this study, the authors present three cases of concurrent/adjacent CNS tumors, review the literature on this topic, and highlight some genomic alterations in that regard. OBSERVATIONS The authors present three cases of patients who had coexistence of meningioma with other glial tumors in this study. LESSONS Coexistence/collision of intracranial and spinal meningiomas with another CNS pathology occurs anecdotally. This phenomenon does not necessarily preclude resection of both tumors in a single session, provided that a careful preoperative assessment of the surgical anatomy is undertaken. Conducting studies to evaluate the genomic structures of such cases and to explain why they occur in adjacency could be valuable in explaining this phenomenon. © 2025 The authors.