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The Pulsed Ultrasound Strategy Effectively Decreases the S. Aureus Population of Chronic Rhinosinusitis Patients Publisher Pubmed



Feizabadi N1 ; Sarrafzadeh J1 ; Fathali M2 ; Vasaghigharamaleki B3 ; Dadgoo M1 ; Kardanyamchi J4 ; Kazemian H5 ; Hesamshariati S4 ; Feizabadi MM4
Authors
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Authors Affiliations
  1. 1. Department of Physiotherapy, Faculty of Rehabilitation, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran
  2. 2. Department of Physiotherapy, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Basic Sciences, Faculty of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran
  5. 5. Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Source: BMC research notes Published:2019


Abstract

OBJECTIVE: Staphylococcus aureus with the ability of biofilm formation and the drug resistance acquisition is one of the most frequently isolated pathogens from chronic rhinosinusitis patients. Ultrasound as an alternative therapy is effectively able to kill the bacteria by cavitation in or on the bacterial cells and peroxide generation and hence improving antibiotic treatment efficacy. RESULTS: Staphylococcus aureus was detected in 4 and 6 out of 14 patients by phenotypic and qPCR assays, respectively. Four patients were completely resolved after pulsed ultrasound treatment. However, presence of the S. aureus was confirmed in three healthy controls by bacterial cultivation. Pulsed ultrasound have been quantitatively decreased the S. aureus population in chronic rhinosinusitis patients (p < 0.05). Further studies need to be investigated the effectiveness of pulsed ultrasound as an alternative course of CRS patient's treatment.