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Multifunctional Core-Shell Nanoplatforms (Gold@Graphene Oxide) With Mediated Nir Thermal Therapy to Promote Mirna Delivery Publisher Pubmed



Assali A1 ; Akhavan O2 ; Adeli M3 ; Razzazan S4 ; Dinarvand R1, 5 ; Zanganeh S6 ; Soleimani M7, 8 ; Dinarvand M9 ; Atyabi F1, 7, 8
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 1417614411, Tehran, Iran
  2. 2. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  3. 3. Institut fur Chemie und Biochemie Organische Chemie Freie Universitat Berlin Takustr. 3, Berlin, Germany
  4. 4. Department of Electrical Engineering, Amirkabir University of Technology, P.O.Box 1591634311, Tehran, Iran
  5. 5. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Science, P.O. Box 14155-6451, Tehran, Iran
  6. 6. Center for Translation of Cancer Nanomedicine, Sloan Kettering Institute for Cancer Research, New York, NY, United States
  7. 7. Stem Cell Technology Research Center, P.O. Box 1997775555, Tehran, Iran
  8. 8. Department of Hematology, School of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran
  9. 9. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2018


Abstract

Recent insights into the nanomedicine have revealed that nanoplatforms enhance the efficacy of carrier in therapeutic applications. Here, multifunctional nanoplatforms were utilized in miRNA-101 delivery and NIR thermal therapy to induce apoptosis in breast cancer cells. Au nanorods (NRs) or nanospheres (NSs) covered with graphene oxide (GO) were prepared and functionalized with polyethylene glycol as a stabilizer and poly-L-arginine (P-L-Arg) as a targeting agent. In nanoplatforms, coupling Au@GO prepared stable structures with higher NIR reactivity. P-L-Arg substantially enhanced the cellular uptake and gene retardation of stuffs coated by them. However, rod-shape nanoplatforms indicated better performance in cellular uptake and gene transfection than spherical ones. NIR thermal therapy was implemented to improve gene release and in synergy with miRNA-101 activated the apoptotic pathway and decreased the viability of breast cancer cell (<20%). Briefly, presented delivery systems are potentially efficient in distinguishing cancer cells, miRNA internalization and controlling apoptosis of cancer cells. © 2018 Elsevier Inc.
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