Evaluation of Lipid Profiles in Patients With Chronic Spontaneous Urticaria: A Case-Control Study; [Оценка Липидного Профиля При Хронической Спонтанной Крапивнице] Publisher



Khalili A¹ ; Davoudabadi FAT¹ ; Sadeghi B^{2, 3} Show Affiliations
Source: Medical Immunology (Russia) Published:2025

Abstract

Chronic urticaria is referred to recurrent, pruritic, erythematous, and edematous mucocutaneous lesions on most days of the week, and persists for six weeks or more. There is a hypothesis about the levels of blood lipid profiles in CSU, which may have a contributing role in development or exacerbation of hives attacks. The present study was conducted to investigate the association between chronic urticaria and blood lipid profiles. Fifty patients with chronic urticaria and fifty healthy people were included in this case-control study. In chronic urticaria patients, each parameters of blood lipid profile and urticaria severity were evaluated in each of four age and two sex cathegories. Urticaria severity in chronic urticaria patients, was also analyzed for levels of HDL, LDL, Triglyceride and Cholesterol. Levels of triglyceride (p value = 0.039), total cholesterol (p value = 0.031), and LDL (p value = 0.001) were significantly higher in chronic urticaria patients than in control group. No correlation was found between the urticaria severity (UAS7 score) average, and the age and sex of the patients. Urticaria severity showed no significant difference within each lipid profile parameter. Average values of lipid profiles in patients with chronic urticaria in different age and sex showed that HDL has remarkably higher mean quantitation in women than men (p < 0.002). Our study found a correlation between chronic urticaria with hyperlipidemia. According to this investigation, we can advise that patients with chronic urticaria should be evaluated for hyperlipidemia. © Abbas Khalili et al., 2025.