Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship

Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review Publisher Pubmed

Boozari M¹ ; Soltani S² ; Iranshahi M³

Show Affiliations

1. Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Phytotherapy Research Published:2019

Abstract

The genus Sophora (Fabaceae) has been used in traditional medicine for years. Prenylated flavonoids are one of the constituents of Sophora species that play important roles in their biological properties. Different classes of prenylated flavonoids are produced by Sophora spp. including prenylated flavonol (e.g., sophoflavescenol), prenylated flavanone (e.g., sophoraflavanone G), prenylated flavonostilbene (e.g., alopecurones A and B), and prenylated chalcone (kuraridin). Prenylated flavonoids have a more lipophilic structure, which leads to its high affinity to the cell membranes and enhancement of the biological activity, which includes cytotoxicity, antibacterial, anti-inflammatory, and estrogenic activities. However, it is reported that prenylation decreases the plasma absorption but increases the tissue accumulation. The presence of the prenyl or lavandulyl groups on C8 position of flavonoids plays an important role in the biological activity. It seems that prenylated flavonoids have the potential to be developed as new drugs or supplements for human health. © 2019 John Wiley & Sons, Ltd.

2. Histone Deacetylase Inhibitory and Cytotoxic Activities of the Constituents From the Roots of Sophora Pachycarpa, Iranian Journal of Pharmaceutical Research (2020)

Style	Citing Format
MLA	Boozari M, Soltani S, Iranshahi M. "Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review." Phytotherapy Research, vol. 33, no. 3, 2019, pp. 546-560.
APA	Boozari M, Soltani S, Iranshahi M (2019). Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review. Phytotherapy Research, 33(3), 546-560.
Chicago	Boozari M, Soltani S, Iranshahi M. "Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review." Phytotherapy Research 33, no. 3 (2019): 546-560.
Harvard	Boozari M, Soltani S, Iranshahi M (2019) 'Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review', Phytotherapy Research, 33(3), pp. 546-560.
Vancouver	Boozari M, Soltani S, Iranshahi M. Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review. Phytotherapy Research. 2019;33(3):546-560.
BibTex	@article{ author = {Boozari M and Soltani S and Iranshahi M}, title = {Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review}, journal = {Phytotherapy Research}, volume = {33}, number = {3}, pages = {546-560}, year = {2019} }
RIS	TY - JOUR AU - Boozari M AU - Soltani S AU - Iranshahi M TI - Biologically Active Prenylated Flavonoids From the Genus Sophora and Their Structure–Activity Relationship—A Review JO - Phytotherapy Research VL - 33 IS - 3 SP - 546 EP - 560 PY - 2019 ER -

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Abstract