Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles

Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles Publisher

Montazeri M¹ ; Razzaghiabyaneh M² ; Nasrollahi SA³ ; Maibach H⁴ ; Nafisi S^{1, 5}

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1. Department of Chemistry, Central Tehran Branch, IAU, Tehran, 14696-69191, Iran
2. Department of Mycology, Pasteur Institute of Iran, Tehran, 13169-43551, Iran
3. Nanodermatology Unit, Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, 14166-13675, Iran
4. Department of Dermatology, University of California, San Francisco, 94115, CA, United States
5. Department of Molecular Bioscience, UC Davis, Davis, 95616, CA, United States

Source: Bulletin of Materials Science Published:2020

Abstract

The present study aims at developing efficient econazole (ECO) platforms as topical creams for the treatment of fungal skin infections. The hexagonal mesoporous silica nanoparticle, known as MCM41, was synthesized and functionalized by aminopropyl groups (MCM41-NH 2). Various ECO concentrations were loaded into MCM41 and MCM41-NH 2 (MSNs); the optimized complexes with the highest entrapment efficiencies were characterized by X-ray powder diffraction, scanning electron microscopy (SEM) and gas-volumetric analysis (BET). SEM images showed a spherical shape of the parent nanoparticles—higher drug loading and incorporation into the nanoparticles were obtained by amino-functionalized MCM41. Cytotoxicity assays of MCM41 and MCM41-NH 2 and the ECO inclusion complexes elucidated no toxicity to human dermal fibroblast cell lines. Enhanced antifungal activity against Candida albicans was observed for ECO/MCM41-NH 2 compared with ECO/MCM41 and simple cream. No irritation was observed by the cream containing ECO/MSN application on white male rabbit skin after 72 h. MSNs were stable within 1 year storage. ECO-loaded silica nanoparticles can be considered for the development of reliable alternatives to ECO cream for the treatment of skin fungal infections. © 2019, Indian Academy of Sciences.

Style	Citing Format
MLA	Montazeri M, et al.. "Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles." Bulletin of Materials Science, vol. 43, no. 1, 2020, pp. -.
APA	Montazeri M, Razzaghiabyaneh M, Nasrollahi SA, Maibach H, Nafisi S (2020). Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles. Bulletin of Materials Science, 43(1), -.
Chicago	Montazeri M, Razzaghiabyaneh M, Nasrollahi SA, Maibach H, Nafisi S. "Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles." Bulletin of Materials Science 43, no. 1 (2020): -.
Harvard	Montazeri M et al. (2020) 'Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles', Bulletin of Materials Science, 43(1), pp. -.
Vancouver	Montazeri M, Razzaghiabyaneh M, Nasrollahi SA, Maibach H, Nafisi S. Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles. Bulletin of Materials Science. 2020;43(1):-.
BibTex	@article{ author = {Montazeri M and Razzaghiabyaneh M and Nasrollahi SA and Maibach H and Nafisi S}, title = {Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles}, journal = {Bulletin of Materials Science}, volume = {43}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Montazeri M AU - Razzaghiabyaneh M AU - Nasrollahi SA AU - Maibach H AU - Nafisi S TI - Enhanced Topical Econazole Antifungal Efficacy by Amine-Functionalized Silica Nanoparticles JO - Bulletin of Materials Science VL - 43 IS - 1 SP - EP - PY - 2020 ER -

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