Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research

Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research Publisher Pubmed

Abdolahi S¹ ; Ghazvinian Z² ; Muhammadnejad S³ ; Saleh M² ; Asadzadeh Aghdaei H¹ ; Baghaei K¹

Show Affiliations

1. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Cell-Based Therapies Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Translational Medicine Published:2022

Abstract

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations. © 2022, The Author(s).

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Style	Citing Format
MLA	Abdolahi S, et al.. "Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research." Journal of Translational Medicine, vol. 20, no. 1, 2022, pp. -.
APA	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K (2022). Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research. Journal of Translational Medicine, 20(1), -.
Chicago	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K. "Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research." Journal of Translational Medicine 20, no. 1 (2022): -.
Harvard	Abdolahi S et al. (2022) 'Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research', Journal of Translational Medicine, 20(1), pp. -.
Vancouver	Abdolahi S, Ghazvinian Z, Muhammadnejad S, Saleh M, Asadzadeh Aghdaei H, Baghaei K. Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research. Journal of Translational Medicine. 2022;20(1):-.
BibTex	@article{ author = {Abdolahi S and Ghazvinian Z and Muhammadnejad S and Saleh M and Asadzadeh Aghdaei H and Baghaei K}, title = {Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research}, journal = {Journal of Translational Medicine}, volume = {20}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Abdolahi S AU - Ghazvinian Z AU - Muhammadnejad S AU - Saleh M AU - Asadzadeh Aghdaei H AU - Baghaei K TI - Patient-Derived Xenograft (Pdx) Models, Applications and Challenges in Cancer Research JO - Journal of Translational Medicine VL - 20 IS - 1 SP - EP - PY - 2022 ER -

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