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Management of Seizures in Patients With Multiple Sclerosis; an Iranian Consensus Publisher Pubmed



Asadipooya AA1, 2 ; Sahraian MA3 ; Sina F4 ; Baghbanian SM5 ; Habibabadi JM6 ; Shaygannejad V7 ; Asadollahi M8 ; Karvigh SA9 ; Moghadasi AN10 ; Nikseresht A11 ; Motamedi M12
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, United States
  3. 3. Multiple Sclerosis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Rasool Akram Hospital, Department of Neurology, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Booalisina Hospital, Department of Neurology, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Isfahan University of Medical Sciences, Isfahan Neurosciences Research Center, Isfahan, Iran
  7. 7. Isfahan Neurosciences research center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Multiple sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Neurology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
  12. 12. Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Epilepsy and Behavior Published:2019


Abstract

Purpose: Cooccurrence of a seizure in a patient with multiple sclerosis (MS) may complicate the management process. Questions, which may complicate the management process of a patient with MS and seizure, include “how should we approach to the patient”, “how should we treat the patient”, “how should we modify the patient's MS treatment strategy”, etc. Methods: We searched the electronic database PubMed on March 30, 2018 for articles in English that included the following search terms: “epilepsy” AND “multiple sclerosis” or “seizure” AND “multiple sclerosis” since 2013, to obtain the best recent relevant scientific evidence on the topic. A working group of 6 epilepsy and 5 MS experts took part in two consensus workshops in Tehran, Iran, in 2018. The final consensus manuscript was prepared and approved by all participants. Results: The search with words “seizure” and “multiple sclerosis” yielded 121 entries; 10 were relevant to the topic. The search with words “epilepsy” and “multiple sclerosis” yielded 400 entries; 7 were relevant to the topic. We reviewed these 17 articles and also some other references, derived from these articles or relevant to the topic, for the purpose of our review. Conclusion: Cooccurrence of a seizure in a patient with MS may complicate the management process. In this review, we tried to provide answers to the frequently asked questions, considering the best available scientific evidence and expert opinion. © 2019 Elsevier Inc.
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