The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis

The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis Publisher

Nazar E¹ ; Khatami F² ; Saffar H¹ ; Tavangar SM^{1, 2}

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2019

Abstract

Transformation of a normal cell to cancerous one is dependent on the accumulation of several genetic and epigenetic alterations. One of the candidate driver genetic alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, and SDHAF2. The most important SDH mutation is in the SDHD gene, which encodes the smallest subunit of mitochondrial complex II (SDH). It has key function both in familial and non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations can have resulted in genetic and epigenetic changes like histone hypermethylation. These properties can lead to succinate-mediated inhibition of a-ketoglutarate-dependent dioxygenases. So hypoxic conditions can generate subsequent neoplastic transformation, and in this review, we are presenting the role of SDHx in several malignancies. © 2019, Tehran University of Medical Sciences (TUMS). All rights reserved.

Style	Citing Format
MLA	Nazar E, et al.. "The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis." International Journal of Hematology-Oncology and Stem Cell Research, vol. 13, no. 2, 2019, pp. 72-82.
APA	Nazar E, Khatami F, Saffar H, Tavangar SM (2019). The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis. International Journal of Hematology-Oncology and Stem Cell Research, 13(2), 72-82.
Chicago	Nazar E, Khatami F, Saffar H, Tavangar SM. "The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis." International Journal of Hematology-Oncology and Stem Cell Research 13, no. 2 (2019): 72-82.
Harvard	Nazar E et al. (2019) 'The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis', International Journal of Hematology-Oncology and Stem Cell Research, 13(2), pp. 72-82.
Vancouver	Nazar E, Khatami F, Saffar H, Tavangar SM. The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis. International Journal of Hematology-Oncology and Stem Cell Research. 2019;13(2):72-82.
BibTex	@article{ author = {Nazar E and Khatami F and Saffar H and Tavangar SM}, title = {The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis}, journal = {International Journal of Hematology-Oncology and Stem Cell Research}, volume = {13}, number = {2}, pages = {72-82}, year = {2019} }
RIS	TY - JOUR AU - Nazar E AU - Khatami F AU - Saffar H AU - Tavangar SM TI - The Emerging Role of Succinate Dehyrogenase Genes (Sdhx) in Tumorigenesis JO - International Journal of Hematology-Oncology and Stem Cell Research VL - 13 IS - 2 SP - 72 EP - 82 PY - 2019 ER -

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