Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Tumor Characteristics and Survival Rate of Axillary Metastatic Breast Cancer Patients: A Three Decades Retrospective Cohort Study Publisher Pubmed



Mousavikiasary SMS1, 2 ; Bayat M2, 7 ; Abbasvandi F2, 3 ; Khoundabi B4 ; Mousavi F1, 2 ; Akbari A2 ; Bagherian M5 ; Zandi A6 ; Honarvar B1 ; Akbari ME2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Cancer Research Center, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. Iran Helal Institute of Applied-Science and Technology, Red Crescent Society of Iran, Tehran, Iran
  5. 5. Department of Hematology and oncology and stem cell transplantation, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Otolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Public Health, School of Public Health and Safety, Shahid Beheshti University of Medical Science, Tehran, Iran

Source: Scientific Reports Published:2025


Abstract

Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. The present study evaluated the characteristics and survival rate of axillary metastatic BC patients in a Tertiary and referral center. Method: The overall survival, disease-free survival, and clinicopathological characteristics of axillary metastatic BC patients referred to the Cancer Research Center in Tehran, Iran, from 1991 to 2022 were assessed retrospectively. We obtained patients’ clinical data from prospectively maintained registries. Result: Among the total 3399 recruited patients, 49.1%, 26.3%,13.1%, and 6.4% were pN0, pN1, pN2 and pN3, respectively. The pN0 group patients showed a significantly lower Hazard Ratio (HR) for DFS and OS compared to others. Moreover, estrogen and progesterone receptors, human epidermal growth factor2, tumor pathology type and tumor grade were prognostic factors of axillary LN status. Accordingly, pN0 patients had a lower recurrence risk than the others (P = 0.01). Conclusion: The axillary lymph node status has been considered as one of the fundamental factors determining the therapeutic strategy and prognosis of BC patients, which has an association with tumor characteristics. Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value. © The Author(s) 2024.
Related Docs
1. Electrical Lymph Node Scanning (Els) System for Real-Time Intra-Operative Detection of Involved Axillary Lymph Nodes in Adjuvant Breast Cancer Patients, Scientific Reports (2024)
2. Intraoperative Pathologically-Calibrated Diagnosis of Lymph Nodes Involved by Breast Cancer Cells Based on Electrical Impedance Spectroscopy; a Prospective Diagnostic Human Model Study, International Journal of Surgery (2021)