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Methylprednisolone Pulse Therapy Can Be Life-Saving in Neonatal Lupus Erythematous: A Case Report Publisher



Kadivar M1, 2 ; Sangsari R1, 2 ; Shahbaznejad L3 ; Ziaee V1, 2, 3
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran
  3. 3. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2017


Abstract

Introduction: Neonatal lupus erythematous (NLE) is a neonatal autoimmune disease, due to passage of maternal autoantibodies against Ro/SS-A, La/SS-B, and U1-ribonucleoprotein, with multi organ involvement. Although the clinical manifestations of NLE include cutaneous, cardiac, hematologic, and hepatobiliary system involvement, the most common clinical manifestations are skin rash and heart involvement. Congenital heart block in the absence of structural cardiac abnormalities is the most commonly observed manifestation. The most clinical manifestations of NLE are self-limited and resolve without serious treatment, except heart block that may need a pacemaker. In rare instances, more severe complications may occur, and necessitate more aggressive immune suppressive therapy. Case Presentation: Here we present a neonate girl who developed cutaneous, cardiac, liver, brain, splenic, kidney, and hematologic abnormalities. After 2 months of aggressive immune suppressive therapy she could be discharged. The treatment was tapered stepwise and discontinued at the age 1 year. At the age of 4 years she was in a favorable health condition. © 2017, Iranian Journal of Pediatrics.