Evaluation of Association Between Adenomyosis and Cesarean Scar Defect Publisher Pubmed



Shakki Katouli F^{1, 2} ; Zebardast J^{1, 3} ; Tavoli Z⁴ ; Bayani L^{1, 2} ; Azizinik F^{1, 5} ; Moradpour M⁶ ; Mardani R^{1, 2} ; Meimani N⁷ ; Fathi S¹
Source: Journal of Ultrasound in Medicine Published:2024

Abstract

Purpose: This study aims to investigate and compare quantitative factors of the cesarean scar defect (CSD) in symptomatic patients with and without uterine adenomyosis. Method: This study was conducted as a case–control study. Patients who met the inclusion criteria were divided into two groups: with adenomyosis (case) and without adenomyosis (control). The demographic data, medical history, and sonohysterography findings were extracted from the patient's documents and archived images. Result: During 2 years, 310 symptomatic women with a history of previous cesarean section underwent sonohysterography. Among them, 204 patients met the inclusion criteria. The most common chief complaints were post-menstrual bleeding (34.3%) and prolonged bleeding (27%). Cesarean scar depth and width significantly differed between these two groups, and patients with underlying adenomyosis had significantly larger defects (P-value of.009 and.005, respectively). Mean RMT/AMT ratio was 31.83% in the case group and 42.88% in the control group. In our study, RMT/AMT ratios were significantly lower in the case group (P-value of.001). In addition, we performed analysis on a subgroup of patients with one prior cesarean section. Similar results were achieved with a lower RMT/AMT ratio in case group (mean of 31.20% in case group and 46.47% in control group; P-value of.000). Conclusion: Our study showed a strong association between the presence of adenomyosis and larger clinically more significant CSDs. To establish a causative relationship, we suggest a prospective cohort study to follow up the patients and compare the evolution of CSD in patients with and without adenomyosis. © 2023 American Institute of Ultrasound in Medicine.