Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
An Interdependence Between Gapvd1 Gene Polymorphism, Expression Level and Response to Interferon Beta in Patients With Multiple Sclerosis Publisher Pubmed



Khademi B1, 2 ; Khorrami M3 ; Ayromlou H4 ; Rikhtegar R5 ; Moghadam EA6 ; Tahmasebivand M2 ; Mousavi SR2 ; Kheirollahi M3 ; Fakhr F3 ; Alizadehghodsi M7 ; Emamalizadeh B2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Immunology research center, Tabriz University of medical science, Tabriz, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Tabriz university of Medical Sciences, Tabriz, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Neurology Department, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Pediatrics, School of Medicine, Children's Medical Center, Tehran university of medical science, Tehran, Iran
  7. 7. Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, The University of Adelaide, Adelaide, 5000, SA, Australia

Source: Journal of Neuroimmunology Published:2021


Abstract

Interferon-β (IFN-β) is among the first drugs used for reducing the symptoms of multiple sclerosis (MS). Many studies show that the genetic predisposition of patients might modulate their response to IFN-β treatment. In this study GAPVD1 gene expression and the genotyping of rs2291858 variant were analysed in 100 responder and 100 non-responder patients with MS treated using IFN-β. Moreover, rs2291858 genotyping was performed for 200 patients with MS and 200 healthy controls. GAPVD1 expression was significantly increased in the responder patients than in non-responders and the distribution of rs2291858 polymorphism was significantly different between them. The GAPVD1 expression level in AA genotype of the responder group was higher than that in other genotypes of these two groups. The results show that the GAPVD1 expression level and rs2291858 genotype probably affect the response to IFN- β in patients with MS. © 2021 Elsevier B.V.
Related Docs
1. Pharmacogenetics: A Strategy for Personalized Medicine for Autoimmune Diseases, Clinical Genetics (2018)
2. A National Registry-Based Study of Ethnic Differences in People With Multiple Sclerosis in Iran, Clinical Neurology and Neurosurgery (2024)
3. Biomechanical Changes of the Common Carotid Artery and Internal Jugular Vein in Patients With Multiple Sclerosis, Ultrasonography (2023)
4. Consensus Recommendations for Diagnosis and Treatment of Multiple Sclerosis: 2023 Revision of the Menactrims Guidelines, Multiple Sclerosis and Related Disorders (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (2)
Sharareh Eskandarieh (1)