Medulloblastoma in Association With Sacral Agenesis; a Case Report Publisher Pubmed



Soltani ZE¹ ; Habibi Z¹ ; Nejat F¹ Show Affiliations
Source: Child's Nervous System Published:2018

Abstract

Medulloblastoma is a congenital brain tumor which can be associated with different congenital anomalies. However, coincidence of cerebellar medulloblastoma with sacral agenesis has not been reported so far. A variety of genetic and/or environmental predisposing factors have been proposed for both diseases. Herein, an unprecedented coincidence of these two conditions is presented. A neonate was born with lumbosacral agenesis, paraplegia, and atrophic legs, and he developed medulloblastoma with three ventricular hydrocephalus 3 years later. Different aspects regarding the embryology and etiology of both ailments are discussed, assuming the possibility that the same genetic and/or environmental risk factors may have played a part in both conditions. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.