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The Effect of Two Doses of Aspirin in Prevention of Preeclampsia in High-Risk Pregnant Women: A Clinical Trial Publisher



M Mirzamoradi MASOUMEH ; H Etemadzadeh HODA ; M Jamali MARZIEH ; R Jamali RAZIEH ; Z Salehi ZAHRA ; K Jafarabady KYANA ; S Sohrabpour SAEED
Authors

Source: Journal of Obstetrics, Gynecology and Cancer Research Published:2025


Abstract

Background & Objective: Nowadays, low-dose aspirin is frequently used to prevent preeclampsia, which is a serious risk factor for adverse maternal and neonatal outcomes. However, the optimal dosage remains unclear. This study was conducted with aim to compare the effect of 80 mg and 120 mg daily doses of aspirin in prevention of preeclampsia in high-risk pregnant women. Materials & Methods: This open-labeled randomized clinical trial was conducted on high-risk pregnant women at 12-16 weeks of gestation. They were assigned to three groups: control, aspirin 80 mg, and aspirin 120 mg. Treatment continued until 36 weeks of gestation and adverse pregnancy outcomes were monitored until delivery. Results: The incidence of preeclampsia in the control group (33%) was significantly (P<0.001) higher than in the aspirin 80 mg (22%) and aspirin 120 mg (17%) groups. However, there was a significantly higher proportion of severe preeclampsia cases with aspirin 120 mg. The frequency of intrauterine growth restriction and preterm labor did not differ significantly among the groups. The most common causes of preterm labor were multiple gestation and spontaneous delivery, with severe preeclampsia accounting for only 11% of cases. There were no significant differences in maternal and neonatal measurements upon delivery. Side effects associated with the use of aspirin were negligible. Conclusion: Daily use of aspirin with doses of 80 mg or 120 mg before the 16th week of gestation in high-risk women reduces the incidence of preeclampsia to a similar extent. As such, 80 mg daily aspirin appear to be sufficient for prevention of preeclampsia in high-risk women. © 2025 Elsevier B.V., All rights reserved.
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