Intraocular Pressure Trend Following Myopic Photorefractive Keratectomy Publisher Pubmed



Fakhraie G¹ ; Vahedian Z¹ ; Zarei R¹ ; Eslami Y¹ ; Tabatabaei SM¹ ; Hadi A¹ ; Ghods S¹ ; Fakhraie A¹ Show Affiliations
Source: International Ophthalmology Published:2022

Abstract

Purpose: To evaluate the intraocular pressure (IOP) trend and risk factors for IOP rise after myopic photorefractive keratectomy (PRK). Patients and methods: One eye of each patient undergone PRK for myopia was randomly assigned to this study. All eyes underwent tonometry by CorVis Scheimpflug Technology (CST) tonometer (Oculus Optikgerate GmbH, Wetzlar, Germany) 1 week, 2 weeks, 1 month, 2 months, 3 months and 4 months after surgery. The eyes with IOP rise more than 5 mmHg and the risk factors were evaluated by Kaplan–Meier graph and multiple Cox regression analysis. Results: A total of 348 eyes of 348 patients were enrolled in this study. Forty-three eyes (12.35%) experienced a steroid-induced IOP rise of more than 5 mmHg. Eyes with IOP rise had higher baseline IOP (Median 19 mmHg (IQR 18–22) versus Median 15 mmHg (IQR 14–16); p < 0.001). Baseline central corneal thickness (CCT) was higher in eyes without IOP rise (Median 520 µm (IQR 509–541) versus Median 535 µm (IQR 518–547); p = 0.009). In multivariate Cox regression analysis, higher baseline IOP was a risk factor for IOP rise (Hazard Ratio (HR) 1.59 (95% CI 1.43–1.77); p < 0.001) while higher baseline CCT was protective (HR 0.97 (95% CI 0.95–0.98); p < 0.001). Conclusion: Eyes with higher baseline IOP and lower baseline CCT are at increased risk of IOP rise after PRK and should be monitored more frequently. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.