A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population

A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population Publisher Pubmed

Hosseini A^{1, 2} ; Shanehbandi D³ ; Estiar MA⁴ ; Gholizadeh S⁵ ; Khabbazi A⁶ ; Khodadadi H⁷ ; Sakhinia E^{6, 7} ; Babaloo Z^{1, 2}

Show Affiliations

1. Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran
2. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran
6. Connective Tissue Disease Research Center, Rheumatology Research Team, Tabriz University of Medical Sciences, Tabriz Genetic Analysis Center (TGAC), Division of Medical Genetics, Faculty of Medicine, Tabriz, Iran
7. Division of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinical Laboratory Published:2015

Abstract

Background: Behcet's Disease (BD) is a rare autoimmune disease that involves the dysfunction of regulatory T cells. FOXP3 is a key transcription factor in the development and function of Treg cells. Recent studies have shown SNPs in the FOXP3 contribute to the susceptibility to some autoimmune disorders. Methods: To clarify the association between the FOXP3 gene and the risk of BD, 50 patients diagnosed with BD and 50 healthy controls from north-western Iran were genotyped by PCR-RFLP (Mun I and Pst I) for two SNPs including rs3761547 (-3499T/C) and rs3761548 (-3279 C/A) in the promoter region of the FOXP3 gene. In addition, a 506 bp nucleotide sequence of FOXP3 promoter was analyzed. Results: The allele-3279 C/A was significantly associated with BD [p = 0.002; odds ratio (OR) = 3.841; 95% confidence interval (CI) 1.610-9.161]; whereas, there was no contribution of the FOXP3 polymorphism-3499T/C to BD [(p = 0.084); (OR = 0.348, 95% CI = 0.101-1.195)]. Meanwhile, sequence analysis showed 100% similarity in both controls and BD patient groups. Conclusions: Therefore, the SNP rs3761548 in the FOXP3 gene appears to contribute to the risk of Behcet's disease among the north-western Iranian population. © Copyright.

2. Genetics and Immunodysfunction Underlying Behcet’S Disease and Immunomodulant Treatment Approaches, Journal of Immunotoxicology (2017)

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5. Microrna Signature of Regulatory T Cells in Health and Autoimmunity, Biomedicine and Pharmacotherapy (2018)

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7. Tumor Necrosis Factor (Tnf)-308, -1031, and Angiotensin-Converting Enzyme (Ace) Dd/Ii Polymorphisms’ Role in Behcet’S Disease With and Without Uveitis: A Meta-Analysis, Ophthalmic Genetics (2020)

8. Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes, Iranian Journal of Immunology (2015)

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Style	Citing Format
MLA	Hosseini A, et al.. "A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population." Clinical Laboratory, vol. 61, no. 12, 2015, pp. 1897-1903.
APA	Hosseini A, Shanehbandi D, Estiar MA, Gholizadeh S, Khabbazi A, Khodadadi H, Sakhinia E, Babaloo Z (2015). A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population. Clinical Laboratory, 61(12), 1897-1903.
Chicago	Hosseini A, Shanehbandi D, Estiar MA, Gholizadeh S, Khabbazi A, Khodadadi H, Sakhinia E, Babaloo Z. "A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population." Clinical Laboratory 61, no. 12 (2015): 1897-1903.
Harvard	Hosseini A et al. (2015) 'A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population', Clinical Laboratory, 61(12), pp. 1897-1903.
Vancouver	Hosseini A, Shanehbandi D, Estiar MA, Gholizadeh S, Khabbazi A, Khodadadi H, et al.. A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population. Clinical Laboratory. 2015;61(12):1897-1903.
BibTex	@article{ author = {Hosseini A and Shanehbandi D and Estiar MA and Gholizadeh S and Khabbazi A and Khodadadi H and Sakhinia E and Babaloo Z}, title = {A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population}, journal = {Clinical Laboratory}, volume = {61}, number = {12}, pages = {1897-1903}, year = {2015} }
RIS	TY - JOUR AU - Hosseini A AU - Shanehbandi D AU - Estiar MA AU - Gholizadeh S AU - Khabbazi A AU - Khodadadi H AU - Sakhinia E AU - Babaloo Z TI - A Single Nucleotide Polymorphism in the Foxp3 Gene Associated Wit] Behcet's Disease in an Iranian Population JO - Clinical Laboratory VL - 61 IS - 12 SP - 1897 EP - 1903 PY - 2015 ER -

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