Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study

Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study Publisher Pubmed

Ghiaseddin A¹ ; Pouri H¹ ; Soleimani M² ; Vasheghanifarahani E¹ ; Ahmadi Tafti H³ ; Hasheminajafabadi S¹

Show Affiliations

1. Biomedical Engineering Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran
2. Hematology Group, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Biochemical and Biophysical Research Communications Published:2017

Abstract

Since the leading cause of death are cardiac diseases, engineered heart tissue (EHT) is one of the most appealing topics defined in tissue engineering and regenerative medicine fields. The importance of EHT is not only for heart regeneration but also for in vitro developing of cardiology. Cardiomyocytes could grow and commit more naturally in their microenvironment rather than traditional cultivation. Thus, this research tried to develop a set up on-a-chip to produce EHT based on chitosan hydrogel. Micro-bioreactor was hydrodynamically designed and simulated by COMSOL and produced via soft lithography process. Chitosan hydrogel was also prepared, adjusted, and assessed by XRD, FTIR and also its degradation rate and swelling ratio were determined. Finally, hydrogels in which mice cardiac progenitor cells (CPC) were loaded were injected into the micro-device chambers and cultured. Each EHT in every chamber was evaluated separately. Prepared EHTs showed promising results that expanded in them CPCs and work as an integrated syncytium. High cell density culture was the main accomplishment of this study. © 2017 Elsevier Inc.

Related Docs

1. Biodegradable Functional Macromolecules As Promising Scaffolds for Cardiac Tissue Engineering, Polymers for Advanced Technologies (2022)

Style	Citing Format
MLA	Ghiaseddin A, et al.. "Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study." Biochemical and Biophysical Research Communications, vol. 484, no. 2, 2017, pp. 225-230.
APA	Ghiaseddin A, Pouri H, Soleimani M, Vasheghanifarahani E, Ahmadi Tafti H, Hasheminajafabadi S (2017). Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study. Biochemical and Biophysical Research Communications, 484(2), 225-230.
Chicago	Ghiaseddin A, Pouri H, Soleimani M, Vasheghanifarahani E, Ahmadi Tafti H, Hasheminajafabadi S. "Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study." Biochemical and Biophysical Research Communications 484, no. 2 (2017): 225-230.
Harvard	Ghiaseddin A et al. (2017) 'Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study', Biochemical and Biophysical Research Communications, 484(2), pp. 225-230.
Vancouver	Ghiaseddin A, Pouri H, Soleimani M, Vasheghanifarahani E, Ahmadi Tafti H, Hasheminajafabadi S. Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study. Biochemical and Biophysical Research Communications. 2017;484(2):225-230.
BibTex	@article{ author = {Ghiaseddin A and Pouri H and Soleimani M and Vasheghanifarahani E and Ahmadi Tafti H and Hasheminajafabadi S}, title = {Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study}, journal = {Biochemical and Biophysical Research Communications}, volume = {484}, number = {2}, pages = {225-230}, year = {2017} }
RIS	TY - JOUR AU - Ghiaseddin A AU - Pouri H AU - Soleimani M AU - Vasheghanifarahani E AU - Ahmadi Tafti H AU - Hasheminajafabadi S TI - Cell Laden Hydrogel Construct On-A-Chip for Mimicry of Cardiac Tissue In-Vitro Study JO - Biochemical and Biophysical Research Communications VL - 484 IS - 2 SP - 225 EP - 230 PY - 2017 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract