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Risk of Coronary Heart Events Based on Rose Angina Questionnaire and Ecg Besides Diabetes and Other Metabolic Risk Factors: Results of a 10-Year Follow-Up in Tehran Lipid and Glucose Study Publisher



Mansournia MA1 ; Holakouienaieni K1 ; Fahimfar N1 ; Almasihashiani A1 ; Cheraghi Z2 ; Ayubi E1 ; Hadaegh F3 ; Eskandari F3 ; Azizi F4 ; Khalili D3, 5
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Endocrinology and Metabolism Published:2017


Abstract

Background: High-risk individuals forCHDcould be diagnosed bysomenon-invasive and low-priced techniques such as Minnesota ECG coding and rose angina questionnaire (RQ). Objectives: The present study aimed at determining the risk of incident CHD according to ECG and RQ besides diabetes and other metabolic risk factors in our population. Methods: Participants comprised of 5431 individuals aged ≥ 30 years within the framework of Tehran lipidandglucose study. Based on their status on history of CHD, ECG, andRQat baseline, all participants were classified to 5 following groups: (1) History-Rose-ECG- (the reference group); (2) History-Rose+ECG-; (3) History-Rose-ECG+; (4) History-Rose+ECG+; and (5) History+. We used Cox regression model to find the role of ECG and RQ on CHD, independent of other risk factors. Results: Overall, 562 CHD events were detected during the median of 10.3 years follow-up. CHD incidence rates were 55.9 and 9.09 cases per 1000 person-year for participants with and without history of CHD, respectively. Hazard ratios (HRs) (95% CIs) were 4.11 (3.27 - 5.11) for History + and 2.18 (1.63 - 2.90), 1.92 (1.47 - 2.51), and 2.48 (1.46 - 4.20) for History-Rose+ECG-, History-Rose-ECG+, and History-Rose+ECG+, respectively. RQ and ECG had the same HRs as high as those for hypertension and hypercholesterolemia; however, diabetes showed statistically and clinically more effects on CVD than RQ and ECG. Conclusions: RQ in general and, ECG especially in asymptomatic patients, were good predictors for CHD events in both Iranian males and females; however, their predictive powers were lower than that of diabetes. © 2017, Research Institute For Endocrine Sciences and Iran Endocrine Society.
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