Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer

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Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer

Niknejad H^{1, 2} ; Yazdanpanah G¹ ; Kakavand M² ; Lavaie Y²

Show Affiliations

1. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Physiology and Pharmacology Published:2016

Abstract

Amniotic epithelial cells (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recently shown that the AECs have anti-cancer properties due to inhibition of angiogenesis, induction of apoptosis and cell cycle arrest probably through inhibition of HSP90. Since the viability of AECs must be improved after in vivo administration in acidic microenvironment of tumor, we clarify here that low pH preconditioning of AECs would lead to more survival of implanted cells in tumor site as well as improved functional outcomes. © 2016, Iranian Society of Physiology and Pharmacology. All rights reserved.

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Style	Citing Format
MLA	Niknejad H, et al.. "Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer." Physiology and Pharmacology, vol. 20, no. 1, 2016, pp. 1-4.
APA	Niknejad H, Yazdanpanah G, Kakavand M, Lavaie Y (2016). Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer. Physiology and Pharmacology, 20(1), 1-4.
Chicago	Niknejad H, Yazdanpanah G, Kakavand M, Lavaie Y. "Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer." Physiology and Pharmacology 20, no. 1 (2016): 1-4.
Harvard	Niknejad H et al. (2016) 'Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer', Physiology and Pharmacology, 20(1), pp. 1-4.
Vancouver	Niknejad H, Yazdanpanah G, Kakavand M, Lavaie Y. Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer. Physiology and Pharmacology. 2016;20(1):1-4.
BibTex	@article{ author = {Niknejad H and Yazdanpanah G and Kakavand M and Lavaie Y}, title = {Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer}, journal = {Physiology and Pharmacology}, volume = {20}, number = {1}, pages = {1-4}, year = {2016} }
RIS	TY - JOUR AU - Niknejad H AU - Yazdanpanah G AU - Kakavand M AU - Lavaie Y TI - Low Ph Preconditioned Amniotic Epithelial Cells for Stem Cell Therapy of Cancer JO - Physiology and Pharmacology VL - 20 IS - 1 SP - 1 EP - 4 PY - 2016 ER -

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