Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion

Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion Publisher

Asgari MS¹ ; Rashidi Ranjbar P¹ ; Rahimi R² ; Mahdavi M³

Show Affiliations

1. School of Chemistry, University College of Chemistry, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. Department of Chemistry, Iran University of Science and Technology, Narmak, Tehran, 16846-13114, Iran
3. Department of Medicinal chemistry, Facaulty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences Tehran, Iran

Source: Applied Organometallic Chemistry Published:2020

Abstract

Cyclocarbopalladation/cross-coupling cascade intramolecular Heck–Suzuki–Miyaura reactions is applied for the first time by palladium immobilized on pyridine-imidazolium ionic liquid supported magnetic iron oxide nanoparticle catalyst (denoted Pd@Py-IL-SPION) for the last step to synthesize trisubstituted arylidene–isoquinolinones derivatives having Combretastatin skeleton. The reaction is performed via propargylamide intermediates prepared by Ugi 4-CR reactions, which undergoes intramolecular Heck–Suzuki–Miyaura domino reaction to produce the desired trisubstituted arylidene-isoquinolinones. The method shows full regio- and stereoselectivity derives from the particular Pd-catalyzed syn-insertion of triple bond. © 2019 John Wiley & Sons, Ltd.

Style	Citing Format
MLA	Asgari MS, et al.. "Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion." Applied Organometallic Chemistry, vol. 34, no. 2, 2020, pp. -.
APA	Asgari MS, Rashidi Ranjbar P, Rahimi R, Mahdavi M (2020). Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion. Applied Organometallic Chemistry, 34(2), -.
Chicago	Asgari MS, Rashidi Ranjbar P, Rahimi R, Mahdavi M. "Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion." Applied Organometallic Chemistry 34, no. 2 (2020): -.
Harvard	Asgari MS et al. (2020) 'Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion', Applied Organometallic Chemistry, 34(2), pp. -.
Vancouver	Asgari MS, Rashidi Ranjbar P, Rahimi R, Mahdavi M. Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion. Applied Organometallic Chemistry. 2020;34(2):-.
BibTex	@article{ author = {Asgari MS and Rashidi Ranjbar P and Rahimi R and Mahdavi M}, title = {Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion}, journal = {Applied Organometallic Chemistry}, volume = {34}, number = {2}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Asgari MS AU - Rashidi Ranjbar P AU - Rahimi R AU - Mahdavi M TI - Synthesis of Arylidene – Isoquinolinones Bearing Combretastatin Skeleton by Cyclocarbopalladation/Cross Coupling Tandem Heck-Suzuki Miaura Reactions Using Nano Catalyst Pd@Py-Il-Spion JO - Applied Organometallic Chemistry VL - 34 IS - 2 SP - EP - PY - 2020 ER -

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