Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices

Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices Publisher

Mashhadi Keshtiban M¹ ; Torky Harchegani P¹ ; Moghimi Zand M¹ ; Azizi Z²

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1. Small Medical Devices, Bio-MEMS & LoC Lab, School of Mechanical Engineering, College of Engineering, University of Tehran, North Kargar St, Tehran, Iran
2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Microfluidics and Nanofluidics Published:2025

Abstract

Contactless dielectrophoresis is an effective method for trapping and manipulating cells in microfluidic devices. However, the efficiency of these devices decreases at higher flow rates. To address the limitation of previous studies, a new pillar shape is introduced and numerically simulated to isolate THP-1 cells and efficiently separate them from red blood cells (RBCs). A comparison is made in two microchannels with the novel pillar shape of two perpendicular ellipses and the circular pillar shape as the reference case. Simulation results demonstrate that the use of two perpendicular ellipticals pillar shape improves the electric characteristics of the device, showing 92.7% higher ∇Erms2 compared to the channel with circular pillars. The working frequency is selected based on the CM factor to isolate THP-1 cells without affecting RBCs. Additionally, the new pillar configuration exhibited 116% higher cell trap efficiency compared to the chip with circular pillars. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

2. Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study, Biosensors (2024)

Experts (# of related papers)

Zahra Azizi Varzaneh (1)

Seyed Mohammad Kazem Aghamir Mohammad Ali (1)

Style	Citing Format
MLA	Mashhadi Keshtiban M, et al.. "Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices." Microfluidics and Nanofluidics, vol. 29, no. 2, 2025, pp. -.
APA	Mashhadi Keshtiban M, Torky Harchegani P, Moghimi Zand M, Azizi Z (2025). Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices. Microfluidics and Nanofluidics, 29(2), -.
Chicago	Mashhadi Keshtiban M, Torky Harchegani P, Moghimi Zand M, Azizi Z. "Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices." Microfluidics and Nanofluidics 29, no. 2 (2025): -.
Harvard	Mashhadi Keshtiban M et al. (2025) 'Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices', Microfluidics and Nanofluidics, 29(2), pp. -.
Vancouver	Mashhadi Keshtiban M, Torky Harchegani P, Moghimi Zand M, Azizi Z. Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices. Microfluidics and Nanofluidics. 2025;29(2):-.
BibTex	@article{ author = {Mashhadi Keshtiban M and Torky Harchegani P and Moghimi Zand M and Azizi Z}, title = {Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices}, journal = {Microfluidics and Nanofluidics}, volume = {29}, number = {2}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Mashhadi Keshtiban M AU - Torky Harchegani P AU - Moghimi Zand M AU - Azizi Z TI - Effects of Pillar Shapes on the Cell Isolation in Contactless Dep Microfluidic Devices JO - Microfluidics and Nanofluidics VL - 29 IS - 2 SP - EP - PY - 2025 ER -

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