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Abbreviated Breast Mri for Evaluating Breast Cancer Before Initiation of Neoadjuvant Chemotherapy: A Cross-Sectional Study Publisher



Arian A1, 2 ; Ghazanfari Hashemi M2 ; Talebi V2 ; Ahmadinejad N1, 2 ; Eslami B3 ; Sedighi N1 ; Omranipour R4
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Authors Affiliations
  1. 1. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Institute, Department of Radiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Breast Disease Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
  4. 4. Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Radiology Open Published:2023


Abstract

Background: Although, there are accumulating evidence about diagnostic role of abbreviated breast magnetic resonance imaging (MRI) in screening setting, the implementation of abbreviated MRI in staging of breast cancer has been poorly elucidated. Objective: To evaluate the diagnostic performance of abbreviated breast MRI in estimating extent of disease before initiation of neoadjuvant chemotherapy. Methods: A total of 54 patients with biopsy-proven main lesion referred to evaluate by standard protocol breast MRI before initiation of neoadjuvant chemotherapy were retrospectively enrolled. From a standard protocol, a data set of abbreviated protocol consisting fat-saturated T1-weighted (T1W) pre-contrast and first two fat-saturated T1W post-contrast series with reconstruction of their subtraction including maximum intensity projection (MIP) were obtained and interpreted. The concordance rate of abbreviated with standard protocol (as a reference standard) were compared. Diagnostic accuracy, sensitivity, specificity, and positive and negative predictive value were calculated, as well. Results: The maximum size of the main mass was 38.6 ± 17.3 and 40.7 ± 17.9 for abbreviated and standard protocol, respectively. All of the main mass was detected by abbreviated protocol with 100% concordance. Concordance was 98.1% and 94.4% in terms of multifocal/multicentric status and for estimating of NME, respectively. The abbreviated protocol has high sensitivity and specificity with more than 90% value regarding main mass detection, measurement of the maximum size of the main mass, determination of multifocal/multicenter status and NAC involvement. Conclusion: Abbreviated protocol may be a reliable surrogate for standard protocol breast MRI in evaluating extent of breast cancer. © 2023 The Authors
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