P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer

P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer Publisher Pubmed

Farzad N^{1, 3} ; Barati N^{1, 2, 3} ; Momtaziborojeni AA⁴ ; Yazdani M¹ ; Arab A^{1, 2, 3} ; Razazan A⁵ ; Shariat S¹ ; Mansourian M^{1, 3} ; Abbasi A¹ ; Saberi Z¹ ; Badiee A^{1, 2, 3} ; Jalali SA⁶ ; Jaafari MR^{1, 2, 3}

Show Affiliations

1. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
4. Nanotechnology Research Center, Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2019

Abstract

The present study was aimed to develop an effective nanoliposomal vaccine delivery system with P435 HER2/neu-derived peptide conjugated to Maleimide-PEG2000-DSPE. The nanoliposome formulation composed of DSPC/DSPG/Chol/DOPE and monophosphoryl lipid A was used as an adjuvant. Liposomal formulations were prepared and their physical properties were characterized. Anti-tumoral efficacy of formulations was evaluated by immunization of tumor-bearing BALB/c mice and the generated immune response was studied by using ELISpot and flow cytometry analysis. The results of the study demonstrated Lip + DOPE + P535 formulation caused the lowest tumor size and the longest survival time in TUBO mice model and could make it a promising candidate in developing effective vaccines against HER2-positive breast cancers. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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Seyed Mahdi Rezayat Sorkhabadi (4)

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Style	Citing Format
MLA	Farzad N, et al.. "P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer." Artificial Cells# Nanomedicine and Biotechnology, vol. 47, no. 1, 2019, pp. 665-673.
APA	Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, Shariat S, Mansourian M, Abbasi A, Saberi Z, Badiee A, Jalali SA, Jaafari MR (2019). P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer. Artificial Cells# Nanomedicine and Biotechnology, 47(1), 665-673.
Chicago	Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, Shariat S, et al.. "P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer." Artificial Cells# Nanomedicine and Biotechnology 47, no. 1 (2019): 665-673.
Harvard	Farzad N et al. (2019) 'P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer', Artificial Cells# Nanomedicine and Biotechnology, 47(1), pp. 665-673.
Vancouver	Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, et al.. P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer. Artificial Cells# Nanomedicine and Biotechnology. 2019;47(1):665-673.
BibTex	@article{ author = {Farzad N and Barati N and Momtaziborojeni AA and Yazdani M and Arab A and Razazan A and Shariat S and Mansourian M and Abbasi A and Saberi Z and Badiee A and Jalali SA and Jaafari MR}, title = {P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {47}, number = {1}, pages = {665-673}, year = {2019} }
RIS	TY - JOUR AU - Farzad N AU - Barati N AU - Momtaziborojeni AA AU - Yazdani M AU - Arab A AU - Razazan A AU - Shariat S AU - Mansourian M AU - Abbasi A AU - Saberi Z AU - Badiee A AU - Jalali SA AU - Jaafari MR TI - P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer JO - Artificial Cells# Nanomedicine and Biotechnology VL - 47 IS - 1 SP - 665 EP - 673 PY - 2019 ER -

Style

Citing Format

MLA

Farzad N, et al.. "P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer." Artificial Cells# Nanomedicine and Biotechnology, vol. 47, no. 1, 2019, pp. 665-673.

APA

Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, Shariat S, Mansourian M, Abbasi A, Saberi Z, Badiee A, Jalali SA, Jaafari MR (2019). P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer. Artificial Cells# Nanomedicine and Biotechnology, 47(1), 665-673.

Chicago

Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, Shariat S, et al.. "P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer." Artificial Cells# Nanomedicine and Biotechnology 47, no. 1 (2019): 665-673.

Harvard

Farzad N et al. (2019) 'P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer', Artificial Cells# Nanomedicine and Biotechnology, 47(1), pp. 665-673.

Vancouver

Farzad N, Barati N, Momtaziborojeni AA, Yazdani M, Arab A, Razazan A, et al.. P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer. Artificial Cells# Nanomedicine and Biotechnology. 2019;47(1):665-673.

BibTex

@article{ author = {Farzad N and Barati N and Momtaziborojeni AA and Yazdani M and Arab A and Razazan A and Shariat S and Mansourian M and Abbasi A and Saberi Z and Badiee A and Jalali SA and Jaafari MR}, title = {P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {47}, number = {1}, pages = {665-673}, year = {2019} }

RIS

TY - JOUR
AU - Farzad N
AU - Barati N
AU - Momtaziborojeni AA
AU - Yazdani M
AU - Arab A
AU - Razazan A
AU - Shariat S
AU - Mansourian M
AU - Abbasi A
AU - Saberi Z
AU - Badiee A
AU - Jalali SA
AU - Jaafari MR
TI - P435 Her2/Neu-Derived Peptide Conjugated to Liposomes Containing Dope As an Effective Prophylactic Vaccine Formulation for Breast Cancer
JO - Artificial Cells# Nanomedicine and Biotechnology
VL - 47
IS - 1
SP - 665
EP - 673
PY - 2019
ER -

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