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Infertility Treatments and Risk of Breast Benign Diseases: A Case‒Control Study Publisher Pubmed



Moini A1, 2, 3 ; Alipour S3, 4 ; Zandi Z5, 11 ; Malekihajiagha A6, 7 ; Kashani L1 ; Shakki Katouli F8, 9 ; Mojtahedi MF1 ; Bayani L9 ; Abedi M9, 10
Authors
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Authors Affiliations
  1. 1. Endocrinology and Female Infertility Unit, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Tehran, Iran
  3. 3. Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Obstetrics and Gynecology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Radiology, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Radiology, Ballarat Base Hospital, Ballarat, VIC, Australia
  11. 11. Arash Women’s Hospital, Rashid Ave, Resalat Highway, Tehran, Tehranpars, Iran

Source: BMC Women's Health Published:2024


Abstract

Background: Theoretically, endocrine fluctuations occurring during infertility treatments, including ovulation induction (OI) and assisted reproductive techniques (ART), could be associated with an increased risk of benign breast diseases (BBDs). To date, no studies have been conducted on this association. Therefore, the present study investigated the association between different types of infertility treatments and BBDs. Methods: This case‒control study was conducted in Arash Women’s Hospital, Tehran, Iran. The case group included infertile women diagnosed with BBDs without atypia, and the control group included infertile women without breast disease. Breast imaging studies (mammography/ultrasound) were performed for BBD screening, and the diagnosis was confirmed by histopathological examination. Study variables were collected retrospectively from medical records, hospital databases, and questionnaires. Results: Finally, 154 infertile women, including 50 cases (BBDs) and 104 controls (no BBDs), were compared. Our data showed that 66% of cases and 61.4% of controls had undergone at least one course of infertility treatment. There was no association between BBD risk and previous infertility treatments (OR = 1.21; 95% CI = 0.59–2.46), ART (OR = 1.14; 95% CI = 0.90–1.44), or OI cycles (OR = 1.13; 95% CI = 0.98–1.32). Stratification by confounding variables did not change these results. Conclusions: It seems that there is no association between BBDs in infertile women and the type, duration, or number of prior infertility treatments; however, considering the small sample size of the study, the clinical significance of this finding should not be neglected. Therefore, we consider it essential to carry out more extensive, detailed, and prospective studies to distinguish the association of BBDs with different infertility treatments and medications. © The Author(s) 2024.
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