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Carotid Intima Media Thickness and Glomerular Filtration Rate: A Baseline Analysis of the Polyiran-L Trial Publisher Pubmed



Dehghan A1, 2 ; Ardekani A3 ; Akabri M4 ; Sadeghi Y1 ; Radmard AR5 ; Merat S6, 7 ; Khoshnia M8 ; Sharafkhah M6 ; Khuzani AS5 ; Poustchi H6, 7 ; Malekzadeh R6, 7, 9 ; Molavi Vardanjani H10
Authors
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Authors Affiliations
  1. 1. MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Medical Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  9. 9. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. MD-MPH Department, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Nephrology Published:2025


Abstract

Background: The relationship between kidney and vascular health is acknowledged, but detailed information is still missing. This study examines the relationship of estimated glomerular filtration rate (eGFR) and carotid intima media thickness, providing insights into the association between atherosclerosis and kidney function. Methods: Participants older than 50 years of age who were part of the PolyIran-L study, a trial nested in the Golestan Cohort Study, were included. The maximal intima media thickness of both common carotid arteries was evaluated using B-mode ultrasonography. Four different cut-off values for abnormal carotid intima media thickness were considered. Correlation of carotid intima media thickness and eGFR was assessed with linear correlation and multivariable binary logistic regression models after adjusting for several confounders. Results: In total, 1562 participants (750 females, 48%) were included in this population-based study. Assuming the eGFR < 45 [mL/min/1.73 m2] group as reference in the crude analysis, those with eGFR ≥ 45 and < 60 [mL/min/1.73 m2] showed an association of being less likely to have carotid intima media thickness above the 0.8 cutoff. However, the fully adjusted analysis showed no significant statistical association between carotid intima media thickness and eGFR. Conclusion: This study did not support the independent association of eGFR and different carotid intima media thickness cutoffs. This pattern may be different in patients with severely decreased eGFR, a subset of cases in which it should be further investigated. © The Author(s) under exclusive licence to Italian Society of Nephrology 2024.
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