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Cell Phone and Wireless Radiation Hazard on Trpv1 Channel Activation: A Scoping Review Study Publisher



Shirbandi K1 ; Rashnoudi AR2 ; Hassanzadeh G2 ; Akbari R3 ; Mobinfar O4 ; Rahim F5, 6
Authors
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Authors Affiliations
  1. 1. International Affairs Department (IAD), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Allied Health Sciences School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Research Center of Thalassemia and Hemoglobinopathy, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Neuroscience and Oxidative Stress Published:2021


Abstract

TRPV1 channel is activated with pH changes, increasing temperature, free radicals, and oxidative stress, and it may be a good measure for detecting the effect of microwave non-ionizing radiation on cellular and molecular responses. The scoping review study aims to survey the influence of mobile and wireless radiation on the TRPV1 channel mechanism. We systematically considered international databases to recognize related studies, including PubMed, Scopus, Cochrane Library, CINAHL, ISI Web of Science, Science Direct from the start, PROSPERO and EMBASE use headings for scientific topics (Mesh). The hunt covered the period from 1980 until 2019. A total of seven studies comprising 137 cases, three in vitro tests on breast cancer cell line Michigan Cancer Foundation-7 (MCF-7), embryonic kidney HEK293 cells and Rabbit polyclonal anti-TRPV1, and four in vivo experimental studies comprising 21 male and 24 female Wistar Albino rats, were included. Two studies indicated cell phones induced mitochondrial ROS, oxidative stress-induced in the hippocampus, mitochondrial apoptosis via activation of TRPV1 in hippocampus and dorsal root ganglion neurons. The cytosolic Ca2+ induced by TRPV1 induced oxidative overactions and apoptosis at a distance of 10 cm from the source of the cells. Our review shows that cell phone and wireless radiation have a possible effect on Ca2+ signaling by TRPV1 channel activation. This reaction may induce ROS, Fenton and Haber-Weiss reaction which increase free radicals' level in the mitochondria. © 2020 Suleyman Demirel University. All rights reserved.
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