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Prognostic Value of Red Blood Cell Distribution Width and D-Dimer in Diffuse Large B-Cell Lymphoma: Systematic Review and Meta-Analysis Publisher Pubmed



Rahchamani M1 ; Sedghi M2 ; Hakimi A3 ; Nejatianfar M4 ; Javaheri T5 ; Tavakoli R6 ; Ahmadi R7 ; Makarem M8 ; Azminaei N9 ; Zahmatkesh Sangani S8 ; Kamandi N10 ; Soleimanian A10 ; Shavaleh R11 ; Foogerdi M12 Show All Authors
Authors
  1. Rahchamani M1
  2. Sedghi M2
  3. Hakimi A3
  4. Nejatianfar M4
  5. Javaheri T5
  6. Tavakoli R6
  7. Ahmadi R7
  8. Makarem M8
  9. Azminaei N9
  10. Zahmatkesh Sangani S8
  11. Kamandi N10
  12. Soleimanian A10
  13. Shavaleh R11
  14. Foogerdi M12
  15. Rahmani K11
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Molecular and Cellular Biology, Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Ray Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Research and Development, Organic Chemistry Hila Pharmaceutical Co, Mashhad, Iran
  5. 5. Department of Genetics, Young Research and Elites Club, Islamic Azad University, Mashhad Branch, Mashhad, Iran
  6. 6. Department of Radiology, Arak University of Medical Sciences, Arak, Iran
  7. 7. Cellular and Molecular, Islamic Azad University of Mashhad, Mashhad, Iran
  8. 8. Health Vice-Chancellor, Torbat-e Jam Faculty of Medical Sciences, Torbat-e Jam, Iran
  9. 9. Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran
  10. 10. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Emergency Medicine, Faculty of Medicine, Birgand University of Medical Sciences, Birjand, Iran

Source: Cancer Reports Published:2024


Abstract

Background: The significant role of red blood cell distribution width (RDW) and D-Dimer as prognostic factors in patients with some blood malignancies has been reported recently. Aim: We designed and performed a meta-analysis to investigate the prognostic roles of RDW and D-Dimer in subjects with diffuse large B-cell lymphoma (DLBCL). Materials and Methods: We systematically reviewed PubMed-Medline, SCOPUS, EMBASE, Web of Science Core Collection, and Google Scholar up to the present to look for publications on prognostic effects of RDW and D-Dimer in DLBCL patients. For investigation of the associations between RDW and D-Dimer with the overall survival (OS) and progression-free survival (PFS) of the DLBCL cases, hazard ratio (HR) with 95% confidence intervals (CIs) was used. Results: We included 13 eligible studies in the present meta-analysis. The results of pooled analysis showed that increased levels of RDW was related to poor OS (HR = 2.01, 95% CI: 1.62–2.48, p value <.01, I2 = 0%) and poor PFS (HR = 1.52, 95% CI: 1.24–1.85, p value <.01, I2 = 16%) among the DLBCL patients. Similarly, a significant relationship was found between increased D-Dimer and poor OS (HR = 2.30, 95% CI: 1.03–5.14, p value <.05, I2 = 95%) of the DLBCL patients as well. In addition, there was no significant heterogeneity in OS (p value H = 0.65) and PFS (p value H = 0.31) related to RDW among studies included in the meta-analysis. Conclusion: Our finding clearly confirmed that elevated RDW levels and D-Dimer were associated with adverse OS and PFS in DLBCL. © 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.
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