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Genetic Aspects of Intervertebral Disc Degeneration Publisher Pubmed



Hanaei S1 ; Abdollahzade S2 ; Khoshnevisan A2 ; Kepler CK3 ; Rezaei N1, 4, 5
Authors
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 14194, Iran
  3. 3. Rothman Institute, Department of Orthopaedic Surgery, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA, United States
  4. 4. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr. Qarib Street, Keshavarz Boulevard, Tehran, 14194, Iran
  5. 5. Universal Scientific Education and Research Network (USERN), Tehran, 1494, Iran

Source: Reviews in the Neurosciences Published:2015


Abstract

Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could play a significant role in the etiology of this disease. Besides, the interactions with environmental factors could make the role of genetic factors more complicated. Genetic variations in disc components could participate in developing degenerative disc disease through altering the normal homeostasis of discs. Gene polymorphisms in disc proteins (collagens I, II, III, IX, and XI), proteoglycans (aggrecan), cytokines (interleukins I, VI, and X), enzymes (matrix metalloproteinases II, III, and IX), and vitamin D receptor seem to play considerable roles in the pathology of this disease. There are also many other investigated genes that could somehow take part in the process. However, it seems that more studies are needed to clarify the exact role of genetics in IVDD. © 2015 by De Gruyter 2015.
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3. Significant Association of Tnf-Α, But Not Other Pro-Inflammatory Cytokines, Single Nucleotide Polymorphisms With Intervertebral Disc Degeneration in Iranian Population, Clinical Neurology and Neurosurgery (2018)
Experts (# of related papers)
Alireza Khoshnevisan (3)
Nima Rezaei (3)