Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis

Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis Publisher

Paydarnia P^{1, 2} ; Mayeli M^{1, 2, 3} ; Shafie M^{1, 2, 3} ; Agah E^{1, 2} ; Hasani SA^{1, 2, 3} ; Jazani MR² ; Sarraf P^{2, 4}

Show Affiliations

1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
3. NeuroTRACT Association, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: eNeurologicalSci Published:2021

Abstract

Background: The ALS diagnostic challenges necessitate more robust diagnostic and prognostic methods. A potential biomarker in this regard is the alterations of ferritin levels in the serum and CSF of patients compared to controls. Methods: The CSF and serum ferritin levels were measured in 50 ALS cases and 50 control patients with predefined exclusion criteria. The ELISA method was utilized for laboratory measurement and was statistically analyzed using the SPSS. Results: Heightened serum ferritin levels in cases were not statistically significant. However, CSF ferritin levels were significantly higher in ALS patients (P < 0.001). Serum ferritin levels were significantly negatively correlated with the disease duration (P = 0.015) and were significantly positively correlated with the disease progression rate (DPR) (P = 0.012). Conclusion: Heightened CSF ferritin levels can be used for the diagnosis of ALS. The correlation between the serum ferritin levels with the DPR and its correlation with the disease duration suggests potential prognostic utilities. © 2021

Style	Citing Format
MLA	Paydarnia P, et al.. "Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis." eNeurologicalSci, vol. 25, no. , 2021, pp. -.
APA	Paydarnia P, Mayeli M, Shafie M, Agah E, Hasani SA, Jazani MR, Sarraf P (2021). Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis. eNeurologicalSci, 25(), -.
Chicago	Paydarnia P, Mayeli M, Shafie M, Agah E, Hasani SA, Jazani MR, Sarraf P. "Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis." eNeurologicalSci 25, no. (2021): -.
Harvard	Paydarnia P et al. (2021) 'Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis', eNeurologicalSci, 25(), pp. -.
Vancouver	Paydarnia P, Mayeli M, Shafie M, Agah E, Hasani SA, Jazani MR, et al.. Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis. eNeurologicalSci. 2021;25():-.
BibTex	@article{ author = {Paydarnia P and Mayeli M and Shafie M and Agah E and Hasani SA and Jazani MR and Sarraf P}, title = {Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis}, journal = {eNeurologicalSci}, volume = {25}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Paydarnia P AU - Mayeli M AU - Shafie M AU - Agah E AU - Hasani SA AU - Jazani MR AU - Sarraf P TI - Alterations of the Serum and Csf Ferritin Levels and the Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis JO - eNeurologicalSci VL - 25 IS - SP - EP - PY - 2021 ER -

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