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Therapeutic Effects of Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus Symptoms: A Double-Blind Randomised Clinical Trial Publisher Pubmed



Khosravi MH1 ; Atefi A2 ; Mehri A3 ; Sodeifian F4 ; Yousefi J5 ; Bagheri Hagh A5 ; Sohrabpour S6 ; Kazemi F7 ; Ajalloueian M8 ; Saeedi M8
Authors
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Authors Affiliations
  1. 1. Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  5. 5. Department of Otorhinolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Clinical Otolaryngology Published:2023


Abstract

Objective: To evaluate the effect of Neurotec® herbal capsule (100 mg twice a day for 3 months) on the tinnitus symptoms in comparison with the placebo. Design: A double-blind randomised clinical trial. Setting: Otolaryngology clinic of Baqiyatallah Hospital. Participants: Patients suffering from subjective tinnitus. Main Outcome Measures: Pure tone audiometry was measured at.5, 1, 2, 4 and 6 kHz frequencies before and after the third month of intervention. In addition, Tinnitus Handicap Inventory (THI) questionnaire as well as visual analogue scale (VAS) for tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated. Results: Finally, 103 (69 males and 34 females) patients with a mean age of 51.33 ± 13.91 years were analysed. In contrast with control group, patients in intervention group showed a remarkable decrease in THI score after 3 months of treatment (p <.05). Although both groups had improvements in VAS scores, mood disturbance, daily tinnitus perception and daily life alteration scores were only improved in the intervention group. The mean pure tone air and bone conduction were not significantly different between the control and the intervention group at baseline and 3 months after the intervention at.5, 1, 2 and 4 kHz (p >.05). Conclusion: A 3-month treatment with Neurotec capsules in addition to patient education is of benefit for managing symptoms in patients with chronic tinnitus. © 2022 John Wiley & Sons Ltd.
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