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Igg4-Related Hypophysitis Publisher Pubmed



Amirbaigloo A1 ; Esfahanian F2 ; Mouodi M2 ; Rakhshani N3 ; Zeinalizadeh M4
Authors
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Authors Affiliations
  1. 1. Endocrinologist, Practicing at Private Office, Karaj, Iran
  2. 2. Department of Endocrinology and Metabolism, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Firoozgar Hospital, Iran University of medical sciences, Tehran, Iran
  4. 4. Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Endocrine Published:2021


Abstract

Hypophysitis is a rare pituitary inflammatory disorder classified in different ways. Immunoglobulin G4-related disease (IgG4-RD), also a rare disease is a systemic fibro-inflammatory condition characterized by infiltration of tissue with IgG4-positive plasma cells; however prevalence of both of them probably is underestimated. In this paper, we present an Iranian patient with biopsy-proven IgG4-related hypophysitis and then review the clinical characteristics, laboratory, imaging, pathologic findings and therapeutic management as well as prognosis of 115 published cases of hypophysitis secondary to IgG4-related disease. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.