Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Side Effects of Covid-19 Vaccines Among Iranian Healthcare Workers: A Retrospective Cohort Study Publisher Pubmed



Roudgari H1 ; Etemad K2 ; Karami M2 ; Mostafavi F2 ; Sotoodeh Ghorbani S2 ; Farhadi Babadi K2 ; Rahimi E2 ; Taherpour N2 ; Fattahi Masoom SM3 ; Habibi M4 ; Kermanpour H5 ; Laripour R6 ; Manoochehri O7 ; Raeeszadeh M8 Show All Authors
Authors
  1. Roudgari H1
  2. Etemad K2
  3. Karami M2
  4. Mostafavi F2
  5. Sotoodeh Ghorbani S2
  6. Farhadi Babadi K2
  7. Rahimi E2
  8. Taherpour N2
  9. Fattahi Masoom SM3
  10. Habibi M4
  11. Kermanpour H5
  12. Laripour R6
  13. Manoochehri O7
  14. Raeeszadeh M8
  15. Salimi A9
  16. Shekarchi B10
  17. Tajernia A11
  18. Zafarghandi MR12
  19. Zali A13
  20. Zarghi A14
  21. Hashemi Nazari SS15
Show Affiliations
Authors Affiliations
  1. 1. Department of Research, IR Iran Medical Council, Genomic Research Center, National Center for Genomic Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Chief Executive Officer, NOBAAN Private Corporation, Tehran, Iran
  4. 4. Department of Photo Healing and Regeneration, Medical Laser Research Center, ACECR, Tehran, Iran
  5. 5. Emergency Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Education, Aja University of Medical Sciences, Tehran, Iran
  7. 7. Chairman of the Board, NOBAAN Private Corporation, Tehran, Iran
  8. 8. Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  9. 9. Chronic Respiratory Diseases Research Center, Anesthesia and Critical Care Department, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Radiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
  11. 11. Iranian Dental Association, Tehran, Iran
  12. 12. Department of Vascular Surgery and Traumatology, Sina General Hospital, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  14. 14. Department of Medicinal and Pharmaceutical Chemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  15. 15. Prevention of Cardiovascular Disease Research Center, Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of infection in developing countries Published:2024


Abstract

INTRODUCTION: This study assessed the incidence and severity of side effects associated with coronavirus disease 2019 (COVID-19) vaccination among healthcare workers registered with the Medical Council of the Islamic Republic of Iran. METHODOLOGY: A retrospective cohort study was conducted on the healthcare workers focusing on the side-effects of COVID-19 vaccines from March to June 2021. Data were collected using online questionnaires. Multivariable logistic regression was used to assess the association between side effects of the vaccines and demographic variables, comorbidities, vaccine type, and history of COVID-19. RESULTS: Out of 42,018 people who were included, 55.85% reported at least one side effect after receiving the first vaccine dose. 4.59% of those with side effects sought diagnostic intervention or were referred to treatment centers. Multivariable logistic regression indicated that being a woman, higher education, having a history of COVID-19 infection, and having comorbidities increased the risk of side effects. The AstraZeneca vaccine significantly increased the risk of side effects compared to the Sputnik vaccine, while the Sinopharm vaccine decreased this risk. The risk of developing a side effect decreased with age. The risk of moderate and severe side effects was significantly associated with gender, younger age, comorbidities, and a history of COVID-19 infection. Moderate and severe side effects were less reported by those who received the Sinopharm vaccine. CONCLUSIONS: Clinical complications after COVID-19 vaccination, directly or indirectly caused by the vaccines, are common. However, the benefits of COVID-19 vaccines greatly outweigh the risk of reversible side effects, especially among the high-risk population. Copyright (c) 2024 Hassan Roudgari, Koorosh Etemad, Manoochehr Karami, Farideh Mostafavi, Sahar Sotoodeh Ghorbani, Kosar Farhadi Babadi, Elham Rahimi, Niloufar Taherpour, Seyed Mahmood Fattahi Masoom, Masoud Habibi, Hossein Kermanpour, Reza Laripour, Omid Manoochehri, Mohammad Raeeszadeh, Alireza Salimi, Babak Shekarchi, Ali Tajernia, Mohammad Reza Zafarghandi, Alireza Zali, Afshin Zarghi, Seyed