Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles

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Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles Publisher

Doraghi F¹ ; Kianmehr E¹ ; Foroumadi A²

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, 1417614411, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Organic Chemistry Frontiers Published:2021

Abstract

A direct metal-free oxidative cross-dehydrogenative coupling of 8-aminoquinolineamides/sulfonamides and acetonitrile is described. This protocol exhibits good tolerance toward various aryl, heteroaryl and aliphatic carboxamide derivatives. Mechanism investigations reveal that the reaction proceeds via a radical pathway. © the Partner Organisations.

Style	Citing Format
MLA	Doraghi F, Kianmehr E, Foroumadi A. "Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles." Organic Chemistry Frontiers, vol. 8, no. 19, 2021, pp. 5424-5431.
APA	Doraghi F, Kianmehr E, Foroumadi A (2021). Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles. Organic Chemistry Frontiers, 8(19), 5424-5431.
Chicago	Doraghi F, Kianmehr E, Foroumadi A. "Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles." Organic Chemistry Frontiers 8, no. 19 (2021): 5424-5431.
Harvard	Doraghi F, Kianmehr E, Foroumadi A (2021) 'Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles', Organic Chemistry Frontiers, 8(19), pp. 5424-5431.
Vancouver	Doraghi F, Kianmehr E, Foroumadi A. Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles. Organic Chemistry Frontiers. 2021;8(19):5424-5431.
BibTex	@article{ author = {Doraghi F and Kianmehr E and Foroumadi A}, title = {Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles}, journal = {Organic Chemistry Frontiers}, volume = {8}, number = {19}, pages = {5424-5431}, year = {2021} }
RIS	TY - JOUR AU - Doraghi F AU - Kianmehr E AU - Foroumadi A TI - Metal-Free Regioselective C5-Cyanoalkylation of the 8-Aminoquinolineamides/Sulfonamides: Via Oxidative Cross-Dehydrogenative Coupling With Alkylnitriles JO - Organic Chemistry Frontiers VL - 8 IS - 19 SP - 5424 EP - 5431 PY - 2021 ER -

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