Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Dose Response Meta-Analysis Publisher



Valisoltani N¹ ; Ghoreishy SM^{2, 3} ; Imani H¹ ; Rajabiharsini A¹ ; Jowshan M¹ ; Travica N⁴ ; Mohammadi H¹ Show Affiliations
Source: Food Science and Nutrition Published:2023

Abstract

This systematic review and dose–response meta-analysis examined the risk of chronic obstructive pulmonary disease (COPD) following dietary fiber intake. Relevant articles were retrieved from a variety of databases, including Scopus, Embase, and Medline, until March 2023. Spirometry was the most frequently used method for determining the presence of COPD. Based on the search, there were a total of 213,912 participants across five separate studies. Random effects model was used to combine the data and a dose–response analysis was further conducted. Five distinct cohort studies were identified. Based on highest versus lowest analysis, there was an inverse correlation between the intake of total fiber (RR, 0.72; 95%, CI: 0.64–0.80), cereal fiber (RR: 0.76, 95% CI 0.68, 0.86), and fruit fiber (RR: 0.75, 95% CI: 0.68, 0.83). Although this result was not significant for vegetable fiber (RR, 0.95; 95% CI, 0.84–1.07). Dose–response analysis revealed that daily increase of 10 g of total dietary fiber, cereal fiber, or fruit fiber reduced the risk of COPD by 26%, 21%, and 37%, respectively. The ROBINS-E tool classified all cohort studies as having a moderate risk of bias. Total fiber, cereal fiber, and fruit fiber intake were found to have low credibility using the NutriGrade tool. Additionally, there is a lack of scientific evidence supporting the use of vegetable fiber. Larger, more comprehensive studies are required to confirm these findings. © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.