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Association Between Porphyromonas Gingivalis in Subgingival Plaque and Coronary Artery Disease: A Case–Control Study Publisher Pubmed



Maboudi A1, 2 ; Eidi M3 ; Lotfizadeh A4 ; Heidari M5 ; Rafiei A6 ; Nabati M7 ; Moosazadeh M8 ; Valadan R6 ; Kardan M9, 10 ; Jabbareh L1, 2
Authors
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Authors Affiliations
  1. 1. Department of Periodontology, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Private Dental Practice, Sari, Iran
  5. 5. Dental Implants Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran
  6. 6. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Department of Cardiovascular Diseases, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
  9. 9. Royan Stem Cell Technology Company, Tehran, Iran
  10. 10. Molecular and Cell Biology Research Center, Homoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Dental and Medical Problems Published:2024


Abstract

Background. Periodontitis is a chronic inflammatory disease of the supporting tissue surrounding the teeth. The disease is caused by specific bacteria, such as Porphyromonas gingivalis, which lead to the destruction of periodontal ligaments and alveolar bone. Objectives. The study aimed to evaluate the relationship between the prevalence of P. gingivalis in subgin-gival plaque and coronary artery disease (CAD). Material and methods. Fifty patients with CAD and 50 healthy controls (non-CAD) participated in this case–control study. The periodontal health in the groups was evaluated through the assessment of the pocket depth (PD), clinical attachment loss (CAL) and bleeding on probing (BoP). The presence of P. gingivalis in subgingival plaque samples was determined through real-time polymerase chain reaction (RT-PCR). The data was analyzed using the χ2 test and the Mann–Whitney U test. Results. The mean PD was 3.30 ±1.55 mm and 3.56 ±0.97 mm in CAD patients and non-CAD sub-jects, respectively (p = 0.028). No significant differences were observed in the CAL (p = 0.858) and BoP (p = 1.000) between the groups. The RT-PCR results revealed the presence of P. gingivalis 16S rDNA in 32% and 22% of the subgingival plaque of patients with CAD and non-CAD, respectively, with a mean concentration of 7.7 × 106. No statistically significant association was observed between the prevalence of P. gingivalis and CAD (p = 0.260). The results of the multiple logistic regression analysis showed an association between CAD and male sex (p = 0.004, odds ratio (OR): 4.163), as well as age (p = 0.011, OR: 1.067). Conclusions. The findings of this study indicated that there is no statistically significant correlation between the prevalence of P. gingivalis in subgingival plaque and CAD. © 2024, Wroclaw University of Medicine. All rights reserved.