Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies

Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies Publisher

Mollazadeh M¹ ; Mohammadikhanaposhtani M² ; Azizian H³ ; Zonouzi A¹ ; Abdolahi Z⁴ ; Nadri H⁴ ; Larijani B⁵ ; Biglar M⁵ ; Mahdavi M⁵

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Chinese Chemical Society Published:2020

Abstract

2,4-Dioxochroman-pyridinium-phenylacetamide derivatives 7a–n were synthesized and evaluated for their in vitro cholinesterase (ChE) inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Obtained results demonstrated that, among the synthesized compounds, two compounds, 7j and 7k, were more potent than the standard drug donepezil against BuChE and did not show cytotoxicity and carcinogenicity. Furthermore, through molecular modeling and molecular dynamic studies. we showed that these compounds can be located deep in the gorge cavity of BuChE and that they interacted with catalytic residues, acyl, and cholin-binding pockets of this enzyme. Support information. © 2020 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Style	Citing Format
MLA	Mollazadeh M, et al.. "Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies." Journal of the Chinese Chemical Society, vol. 67, no. 10, 2020, pp. 1910-1928.
APA	Mollazadeh M, Mohammadikhanaposhtani M, Azizian H, Zonouzi A, Abdolahi Z, Nadri H, Larijani B, Biglar M, Mahdavi M (2020). Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies. Journal of the Chinese Chemical Society, 67(10), 1910-1928.
Chicago	Mollazadeh M, Mohammadikhanaposhtani M, Azizian H, Zonouzi A, Abdolahi Z, Nadri H, Larijani B, Biglar M, Mahdavi M. "Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies." Journal of the Chinese Chemical Society 67, no. 10 (2020): 1910-1928.
Harvard	Mollazadeh M et al. (2020) 'Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies', Journal of the Chinese Chemical Society, 67(10), pp. 1910-1928.
Vancouver	Mollazadeh M, Mohammadikhanaposhtani M, Azizian H, Zonouzi A, Abdolahi Z, Nadri H, et al.. Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies. Journal of the Chinese Chemical Society. 2020;67(10):1910-1928.
BibTex	@article{ author = {Mollazadeh M and Mohammadikhanaposhtani M and Azizian H and Zonouzi A and Abdolahi Z and Nadri H and Larijani B and Biglar M and Mahdavi M}, title = {Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies}, journal = {Journal of the Chinese Chemical Society}, volume = {67}, number = {10}, pages = {1910-1928}, year = {2020} }
RIS	TY - JOUR AU - Mollazadeh M AU - Mohammadikhanaposhtani M AU - Azizian H AU - Zonouzi A AU - Abdolahi Z AU - Nadri H AU - Larijani B AU - Biglar M AU - Mahdavi M TI - Design and Synthesis of 2,4-Dioxochroman-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: In Vitro and in Silico Studies JO - Journal of the Chinese Chemical Society VL - 67 IS - 10 SP - 1910 EP - 1928 PY - 2020 ER -

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