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Cutaneous Metaplastic Synovial Cyst: A Case Report



Majdi M1 ; Saffar H1 ; Ghanadan A1, 2
Authors
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Authors Affiliations
  1. 1. Dept. of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran, Iran
  2. 2. Dept. of Dermatopathology, Razi Skin Hospital, Tehran, Iran

Source: Iranian Journal of Pathology Published:2016

Abstract

Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 year old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immunohistochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts. © 2017, IRANIAN JOURNAL OF PATHOLOGY.