Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis

Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis Publisher Pubmed

Gholami A^{1, 2, 3} ; Zamani F⁴ ; Hosseini B⁵ ; Sharafkhani R⁶ ; Maadi M⁴ ; Moosavi Jahromi Z^{7, 8} ; Khazaeepool M⁹ ; Sohrabi M⁴

Show Affiliations

1. Department of Public Health, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran
2. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
3. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Gastrointestinal and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Beh Afarin Ave., Tehran, Iran
5. Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
6. PhD in Epidemiology, Khoy University of Medical Sciences, Khoy, Iran
7. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
8. School of Public Health, Zabol University of Medical Sciences, Zabol, Iran
9. Department of Health Education and Promotion, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Medical Principles and Practice Published:2018

Abstract

Objective: This study was designed to examine the effect of metabolic syndrome (MetS) on health-related quality of life (HRQOL) in patients with suspected nonalcoholic steatohepatitis (NASH). Subjects and Methods: Three hundred thirty-two patients (236 males and 96 females) with suspected NASH from the Amol cohort study were included in this study. MetS was diagnosed based on Adult Treatment Panel III criteria and HRQOL was measured using the 12-Item Short-Form Health Survey (SF-12) questionnaire (with 8 subscales and 2 summary components). A multivariable linear regression model was used to assess the independent effect of MetS on HRQOL. Results: The mean age of the study population was 42 ± 13 years (range 18-82). The prevalence of MetS was 43.4% (n = 144) and the mean scores on the Physical Component Summary (PCS) and the Mental Component Summary were 72.4 ± 20.86 and 42.7 ± 12.42, respectively. The multivariable linear regression model showed that MetS was negatively associated with 4 subscales of HRQOL that included: role limitations due to physical problems (RP) (B = -14.05, p = 0.004), bodily pain (BP) (B = -7.37, p = 0.02), vitality (VT) (B = -7.72, p = 0.022), and role limitations due to emotional problems (RE) (B = -12.67, p = 0.005) after adjustment for other variables. Also, MetS had a borderline association with the general health and mental health subscales and the PCS (p < 0.1). Conclusion: In this study, there was a strong association between MetS and 4 subscales (RP, BP, VT, and RE) of HRQOL in patients with suspected NASH; this could be considered as a part of health policy to improve general health. © 2018 The Author(s) Published by S. Karger AG, Basel.

Related Docs

1. Impact of Standard Treatment on the Quality of Life of Non-Alcoholic Fatty Liver Disease Patients, Journal of Taibah University Medical Sciences (2021)

2. Advancing the Global Public Health Agenda for Nafld: A Consensus Statement, Nature Reviews Gastroenterology and Hepatology (2022)

Experts (# of related papers)

View all Related Experts

Reza Malekzadeh (1)

Raika Jamali (1)

Style	Citing Format
MLA	Gholami A, et al.. "Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis." Medical Principles and Practice, vol. 27, no. 2, 2018, pp. 166-172.
APA	Gholami A, Zamani F, Hosseini B, Sharafkhani R, Maadi M, Moosavi Jahromi Z, Khazaeepool M, Sohrabi M (2018). Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis. Medical Principles and Practice, 27(2), 166-172.
Chicago	Gholami A, Zamani F, Hosseini B, Sharafkhani R, Maadi M, Moosavi Jahromi Z, Khazaeepool M, Sohrabi M. "Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis." Medical Principles and Practice 27, no. 2 (2018): 166-172.
Harvard	Gholami A et al. (2018) 'Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis', Medical Principles and Practice, 27(2), pp. 166-172.
Vancouver	Gholami A, Zamani F, Hosseini B, Sharafkhani R, Maadi M, Moosavi Jahromi Z, et al.. Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis. Medical Principles and Practice. 2018;27(2):166-172.
BibTex	@article{ author = {Gholami A and Zamani F and Hosseini B and Sharafkhani R and Maadi M and Moosavi Jahromi Z and Khazaeepool M and Sohrabi M}, title = {Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis}, journal = {Medical Principles and Practice}, volume = {27}, number = {2}, pages = {166-172}, year = {2018} }
RIS	TY - JOUR AU - Gholami A AU - Zamani F AU - Hosseini B AU - Sharafkhani R AU - Maadi M AU - Moosavi Jahromi Z AU - Khazaeepool M AU - Sohrabi M TI - Metabolic Syndrome Is Associated With Health-Related Quality of Life in Suspected Patients With Nonalcoholic Steatohepatitis JO - Medical Principles and Practice VL - 27 IS - 2 SP - 166 EP - 172 PY - 2018 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract