The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy

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The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy Publisher Pubmed

Behnam M¹ ; Motamedzadeh A² ; Aalinezhad M³ ; Dadgostar E^{4, 5} ; Rashidi Noshabad FZ¹ ; Pourfridoni M⁶ ; Raei M⁷ ; Mirzaei H⁸ ; Aschner M⁹ ; Tamtaji OR^{10, 11}

Source: Molecular Biology Reports Published:2022

Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.

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Style	Citing Format
MLA	Behnam M, et al.. "The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy." Molecular Biology Reports, vol. 49, no. 11, 2022, pp. 10609-10615.
APA	Behnam M, Motamedzadeh A, Aalinezhad M, Dadgostar E, Rashidi Noshabad FZ, Pourfridoni M, Raei M, Mirzaei H, Aschner M, Tamtaji OR (2022). The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy. Molecular Biology Reports, 49(11), 10609-10615.
Chicago	Behnam M, Motamedzadeh A, Aalinezhad M, Dadgostar E, Rashidi Noshabad FZ, Pourfridoni M, Raei M, Mirzaei H, Aschner M, Tamtaji OR. "The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy." Molecular Biology Reports 49, no. 11 (2022): 10609-10615.
Harvard	Behnam M et al. (2022) 'The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy', Molecular Biology Reports, 49(11), pp. 10609-10615.
Vancouver	Behnam M, Motamedzadeh A, Aalinezhad M, Dadgostar E, Rashidi Noshabad FZ, Pourfridoni M, et al.. The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy. Molecular Biology Reports. 2022;49(11):10609-10615.
BibTex	@article{ author = {Behnam M and Motamedzadeh A and Aalinezhad M and Dadgostar E and Rashidi Noshabad FZ and Pourfridoni M and Raei M and Mirzaei H and Aschner M and Tamtaji OR}, title = {The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy}, journal = {Molecular Biology Reports}, volume = {49}, number = {11}, pages = {10609-10615}, year = {2022} }
RIS	TY - JOUR AU - Behnam M AU - Motamedzadeh A AU - Aalinezhad M AU - Dadgostar E AU - Rashidi Noshabad FZ AU - Pourfridoni M AU - Raei M AU - Mirzaei H AU - Aschner M AU - Tamtaji OR TI - The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy JO - Molecular Biology Reports VL - 49 IS - 11 SP - 10609 EP - 10615 PY - 2022 ER -

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